Feasibility of helical tomotherapy for debulking irradiation before stem cell transplantation in malignant lymphoma

International Journal of Radiation Oncology, Biology, Physics
C ChargariYoulia M Kirova

Abstract

Preliminary clinical experience has suggested that radiation therapy (RT) may be effectively incorporated into conditioning therapy before transplant for patients with refractory/relapsed malignant lymphoma. We investigated the feasibility of debulking selective lymph node irradiation before autologous and/or allogeneic stem cell transplantation (SCT) using helical tomotherapy (HT). Six consecutive patients with refractory malignant lymphoma were referred to our institution for salvage HT before SCT. All patients had been previously heavily treated but had bulky residual tumor despite chemotherapy (CT) intensification. Two patients had received previous radiation therapy. HT delivered 30-40 Gy in the involved fields (IF), using 6 MV photons, 2 Gy per daily fraction. Total duration of treatment was 28 to 35 days. Using HT, doses to critical organs (heart, lungs, esophagus, and parotids) were significantly decreased and highly conformational irradiation could be delivered to all clinical target volumes. HT delivery was technically possible, even in patients with lesions extremely difficult to irradiate in other conditions or in patients with previous radiation therapy. No Grade 2 or higher toxicity occurred. Four months after the...Continue Reading

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Dec 31, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Punit D WadhwaHillard M Lazarus
Nov 21, 2007·Haematologica·Norbert SchmitzAnna Sureda
Mar 12, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bradford S HoppeJoachim Yahalom
Feb 5, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cyrus ChargariYoulia M Kirova
Mar 17, 2009·European Journal of Haematology·Cyrus ChargariAlain Fourquet

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Citations

Jan 15, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A ServyY M Kirova
Oct 21, 2015·Radiation Oncology Journal·Tony Eng, Chul S Ha

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