Feasibility of magnetoencephalographic source imaging in patients with thalamic deep brain stimulation for epilepsy

Epilepsia Open
Richard WennbergLuis Garcia Dominguez

Abstract

Source localization of interictal spikes in patients with medically refractory epilepsy is the most common clinical application of magnetoencephalography (MEG). In recent decades, many patients with intractable epilepsy have been treated with various forms of neurostimulation, including thalamic deep brain stimulation (DBS). Patients with suboptimal seizure control after DBS might in some cases benefit from further investigations for resective epilepsy surgery, including MEG source imaging (MSI). We sought to determine the feasibility and accuracy of MSI in the setting of active thalamic DBS. Simultaneous EEG/MEG was obtained in a patient using an Elekta 306-channel MEG system, with high-frequency (100 Hz) DBS of the thalamic anterior nuclei cycling between on and off states. Magnetic artifacts associated with the DBS apparatus were successfully suppressed using the spatiotemporal signal space separation (tSSS) method. Electrical stimulation artifact was removed by standard digital low-pass filtering. Dipole source modeling results for spike foci in frontal and posterior temporal regions were comparable between stimulation on and stimulation off states, and the source solutions corresponded well to the localization of spikes do...Continue Reading

References

Jun 13, 2002·Epilepsia·Mojgan HodaieAndres M Lozano
Oct 13, 2009·Pediatric Neurology·Naoaki TanakaSteven M Stufflebeam
Jul 21, 2010·Human Brain Mapping·Katja AiraksinenEero Pekkonen
Dec 7, 2010·Epilepsy Research·Evelien CarretteKristl Vonck
Apr 20, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katja AiraksinenJyrki P Mäkelä
Nov 12, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Richard Wennberg, Douglas Cheyne
Apr 12, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Richard Wennberg, Douglas Cheyne
Sep 15, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katja AiraksinenEero Pekkonen
Sep 15, 2014·Journal of Neuroscience Methods·Yinming SunZafiris J Daskalakis
Jan 4, 2015·Epilepsy & Behavior : E&B·Siddharth Kharkar, Robert Knowlton
Apr 20, 2016·Journal of Neuroscience Methods·Omid AbbasiMarkus Butz

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Citations

Dec 16, 2018·Journal of Magnetic Resonance Imaging : JMRI·Ileana HancuRadhika Madhavan
Dec 18, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Richard WennbergJ Martin Del Campo

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Methods Mentioned

BETA
X‐ray

Software Mentioned

Elekta Maxfilter
CURRY
sLORETA
LORETA

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