Feasibility of minocycline and doxycycline use as potential vasculostatic therapy for brain vascular malformations: pilot study of adverse events and tolerance.

Cerebrovascular Diseases
Tim FrenzelWilliam L Young

Abstract

Tetracyclines may be useful in preventing pathological vascular remodeling, thus decreasing the risk of spontaneous hemorrhage from brain vascular malformations. Arteriovenous malformation (AVM) and intracranial aneurysm patients undergoing noninvasive management were treated with minocycline or doxycycline (200 mg/day) up to 2 years in a prospective open-label safety pilot trial. The primary outcome was to compare dose-limiting intolerance, defined as treatment-related dose reduction or withdrawal between the agents. Twenty-six patients with AVMs (n = 12) or aneurysms (n = 14) were recruited. Adverse event rates were similar to other reported trials of these agents; 4 of 13 (31%) minocycline and 3 of 13 (23%) doxycycline patients had dose-limiting intolerance (hazard ratio = 3.1, 95% CI = 0.52-18.11, log rank p = 0.70). It is feasible to propose a long-term trial to assess the potential benefit of tetracycline therapy to decrease hemorrhagic risk in brain vascular malformations.

References

Jul 1, 1991·Antimicrobial Agents and Chemotherapy·R BöckerD Ludewig-Sandig
Mar 13, 1999·Archives of Internal Medicine·M C SturkenboomB H Stricker
Jul 16, 1999·Seminars in Arthritis and Rheumatism·O ElkayamD Caspi
Nov 5, 1999·Neurosurgery·D ChyatteD R Todor
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·J YrjänheikkiJ Koistinaho
Mar 30, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Jaspersen
May 23, 2002·Brain : a Journal of Neurology·Veronika BrundulaV Wee Yong
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Mar 12, 2003·Neurology·Raphael M BonelliFranz Reisecker
Jun 5, 2003·Annals of Neurology·Christopher PowerJames Peeling
Jul 18, 2003·Lancet·David O WiebersUNKNOWN International Study of Unruptured Intracranial Aneurysms Investigators
May 29, 2004·Stroke; a Journal of Cerebral Circulation·Alexander X HalimWilliam L Young
Jan 26, 2005·BMC Neurology·Tomoki HashimotoUNKNOWN University of California, San Francisco, BAVM Study Group
Nov 18, 2005·Clinical Therapeutics·Kelly Smith, James J Leyden
May 25, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Yongmei ChenWilliam L Young

❮ Previous
Next ❯

Citations

Jan 12, 2013·Current Neurology and Neuroscience Reports·J P MohrJ Pile-Spellman
Mar 3, 2011·The Journal of Pharmacology and Experimental Therapeutics·Wilfried BriestMark I Talan
Jul 14, 2010·Journal of Neurointerventional Surgery·C A PotterS W Hetts
Dec 10, 2008·Stroke; a Journal of Cerebral Circulation·Helen KimWilliam L Young
Oct 17, 2009·Stroke; a Journal of Cerebral Circulation·Gabrielle G LeblancUNKNOWN Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators
Jul 17, 2010·Stroke; a Journal of Cerebral Circulation·J P MohrJonathan L Brisman
Jul 17, 2012·Stroke; a Journal of Cerebral Circulation·Hiroshi MakinoTomoki Hashimoto
Dec 11, 2013·Translational Stroke Research·Nima EtminanR Loch Macdonald
Apr 12, 2014·Translational Stroke Research·Wanqiu ChenHua Su
Aug 15, 2014·Current Cardiology Reports·Jose Gutierrez
Jul 9, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Thomas J BuellKenneth C Liu
Dec 17, 2014·Seminars in Pediatric Neurology·Joseph J Melvin, H Huntley Hardison
May 15, 2012·Epilepsy & Behavior : E&B·Doris D WangWilliam L Young
Jan 1, 2015·Nature Reviews. Disease Primers·Michael T LawtonRobert F Spetzler
Apr 10, 2015·Current Treatment Options in Neurology·Andreas Hartmann, J P Mohr
Jul 28, 2012·Drug Discovery Today·Julie Blatt, Seth J Corey
Jan 10, 2014·Neurosurgery·Benjamin A RubinDouglas Kondziolka
Sep 11, 2019·The Cochrane Database of Systematic Reviews·Susanna M Zuurbier, Rustam Al-Shahi Salman
May 21, 2020·Neurosurgery·Daniel M S RaperAdib A Abla
Dec 22, 2020·Journal of Cellular Physiology·S Krithika, S Sumi
Jun 25, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peipei PanHua Su
May 17, 2021·Mayo Clinic Proceedings·Rabih G TawkWilliam D Freeman
Nov 18, 2021·Stroke; a Journal of Cerebral Circulation·Vani Venugopal, S Sumi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.