Feasibility of Multiparametric Positron Emission Tomography/Magnetic Resonance Imaging as a One-Stop Shop for Radiation Therapy Planning for Patients with Head and Neck Cancer.

International Journal of Radiation Oncology, Biology, Physics
Anders B OlinFlemming L Andersen

Abstract

Multiparametric positron emission tomography (PET)/magnetic resonance imaging (MRI) as a one-stop shop for radiation therapy (RT) planning has great potential but is technically challenging. We studied the feasibility of performing multiparametric PET/MRI of patients with head and neck cancer (HNC) in RT treatment position. As a step toward planning RT based solely on PET/MRI, a deep learning approach was employed to generate synthetic computed tomography (sCT) from MRI. This was subsequently evaluated for dose calculation and PET attenuation correction (AC). Eleven patients, including 3 pilot patients referred for RT of HNC, underwent PET/MRI in treatment position after a routine fluorodeoxyglucose-PET/CT planning scan. The PET/MRI scan protocol included multiparametric imaging. A convolutional neural network was trained in a leave-one-out process to predict sCT from the Dixon MRI. The clinical CT-based dose plans were recalculated on sCT, and the plans were compared in terms of relative differences in mean, maximum, near-maximum, and near-minimum absorbed doses for different volumes of interest. Comparisons between PET with sCT-based AC and PET with CT-based AC were assessed based on the relative differences in mean and maxim...Continue Reading

References

Nov 22, 1997·International Journal of Radiation Oncology, Biology, Physics·C RaschJ V Lebesque
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·C C LingJ A Koutcher
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jean-François DaisneVincent Grégoire
Feb 3, 2005·The Lancet Oncology·Søren M Bentzen
Apr 29, 2005·Radiology·Barton F BranstetterCarolyn C Meltzer
Jun 29, 2005·Seminars in Radiation Oncology·Coen RaschMarcel van Herk
Nov 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Søren M Bentzen
May 16, 2006·Medical Physics·Jonathan P J CarneyBernard Bendriem
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Oct 13, 2009·Computer Methods and Programs in Biomedicine·Marc ModatSébastien Ourselin
Nov 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Anuradha ThiagarajanNancy Lee
Jul 6, 2014·Medical Physics·Daniel H PaulusHarald H Quick
Oct 16, 2015·International Journal of Radiation Oncology, Biology, Physics·Indrin J ChettyJohn W Wong
Apr 8, 2016·Physics in Medicine and Biology·Daniel H PaulusHarald H Quick
Jan 28, 2017·Radiation Oncology·Jens M Edmund, Tufve Nyholm
Mar 1, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·F GuerreiroA C Knopf
Apr 21, 2017·Physics in Medicine and Biology·John S GinnJames M Lamb
Aug 28, 2017·International Journal of Radiation Oncology, Biology, Physics·Emilia PerssonJoakim Jonsson
May 12, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·René M WinterDaniela Thorwarth
Jun 5, 2018·Medical Physics·Patrik BrynolfssonTufve Nyholm
Aug 16, 2018·International Journal of Radiation Oncology, Biology, Physics·Anna M DinklaCornelis A T van den Berg
Oct 28, 2018·Medical Physics·Berkman SahinerMaryellen L Giger
Nov 30, 2018·International Journal of Radiation Oncology, Biology, Physics·Mary AdjeiwaahTufve Nyholm
Jan 23, 2019·Frontiers in Neuroscience·Claes Nøhr LadefogedFlemming Littrup Andersen
Jun 4, 2019·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Anders OlinAdam E Hansen

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Citations

Mar 26, 2021·Frontiers in Oncology·Daniela Thorwarth, Daniel A Low
Jun 11, 2021·Acta Oncologica·Sahar AhangariAdam Espe Hansen
Jun 20, 2021·Journal of Medical Imaging and Radiation Oncology·Phillip ChlapAnnette Haworth

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