Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms.

Biomedical Optics Express
Marjan RazaniMichael C Kolios

Abstract

In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a 20 MHz piezoelectric transducer (circular element 8.5 mm diameter) transmitting sine-wave bursts of 400 μs, synchronized with the OCT swept source wavelength sweep. The acoustic radiation force (ARF) was applied to two gelatin phantoms (differing in gelatin concentration by weight, 8% vs. 14%). Differential OCT phase maps, measured with and without the ARF, demonstrate microscopic displacement generated by shear wave propagation in these phantoms of different stiffness. We present preliminary results of OCT derived shear wave propagation velocity and modulus, and compare these results to rheometer measurements. The results demonstrate the feasibility of shear wave OCE (SW-OCE) for high-resolution microscopic homogeneous tissue mechanical property characterization.

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Citations

Jul 30, 2014·Biomedical Optics Express·Adeel AhmadStephen A Boppart
Dec 5, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Bastien ArnalMatthew O'Donnell
Nov 21, 2014·Journal of Biophotonics·Shang Wang, Kirill V Larin
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Dec 25, 2017·Journal of Biomedical Optics·Mitchell A KirbyMatthew O'Donnell
Mar 9, 2017·Biomedical Optics Express·Kirill V Larin, David D Sampson
Mar 25, 2020·Biomedical Optics Express·Hsiao-Chuan LiuMatthew W Urban
Jul 9, 2014·Journal of Biomedical Optics·Brendan F KennedyDavid D Sampson
Apr 28, 2020·Light, Science & Applications·Yan LiZhongping Chen
Apr 14, 2021·Light, Science & Applications·Yan LiZhongping Chen
Oct 2, 2021·Optics Letters·Fen YangDa Xing

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Methods Mentioned

BETA
imaging technique

Software Mentioned

MATLAB

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