Feasibility of optical coherence tomography angiography to assess changes in retinal microcirculation in ovine haemorrhagic shock

Critical Care : the Official Journal of the Critical Care Forum
M AlnawaisehMichael Hessler

Abstract

This study aimed to investigate the feasibility of optical coherence tomography angiography (OCT-A) for quantitative analysis of flow density to assess changes in retinal perfusion in an experimental model of haemorrhagic shock. Haemorrhagic shock was induced in five healthy, anaesthetized sheep by stepwise blood withdrawal of 3 × 10 ml∙kg- 1 body weight. OCT-A imaging of retinal perfusion was performed using an OCT device. Incident dark-field illumination microscopy videos were obtained for the evaluation of conjunctival microcirculation. Haemodynamic variables and flow density data in the OCT angiogram were analysed before and during progressive haemorrhage resulting in haemorrhagic shock as well as after fluid resuscitation with 10 ml∙kg- 1 body weight of balanced hydroxyethyl starch solution (6% HES 130/0.4). Videos of the conjunctival microcirculation were recorded at baseline, in haemorrhagic shock, and after resuscitation. Data are presented as median with interquartile range. Comparisons between time points were made using Friedman's test and the degree of correlation between two variables was expressed as Spearman's rank correlation coefficient. Mean arterial pressure and cardiac index (CI) decreased and lactate concen...Continue Reading

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Citations

May 30, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Michael HesslerMaged Alnawaiseh
Aug 10, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Maged Alnawaiseh
Dec 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Viktoria C BrücherMaged Alnawaiseh
Oct 21, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jost L LauermannM Alnawaiseh
Dec 7, 2018·Journal of Alzheimer's Disease : JAD·Larissa LahmeMaged Alnawaiseh
Dec 16, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Wenbo ZhangLiu Yang
Nov 11, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M AlnawaisehC Mardin
Feb 23, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Martin Dominik LeclaireMaged Alnawaiseh
Apr 8, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Junichi ShimamuraEisuke Tatsumi
Apr 22, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Maged AlnawaisehNicole Eter
Jul 9, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maged AlnawaisehPhilipp Sebastian Lange
Aug 28, 2021·Diagnostics·Ella F CourtieRichard J Blanch
May 20, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kento WatanabeYuichi Hori

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AVA
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