Feasibility of Pegylated Interferon in Children and Young Adults With Resected High-Risk Melanoma

Pediatric Blood & Cancer
Fariba NavidAlberto Pappo

Abstract

Pegylated interferon α-2b (IFN α-2b) improves disease-free survival in adults with resected stage III melanoma. We conducted a study to determine the feasibility and safety of incorporating pegylated IFN α-2b as adjuvant therapy in the treatment of children and adolescents with high-risk melanoma. Pharmacokinetic studies of IFN α-2b and neuropsychological and quality of life (OL) assessments were performed. Eligible patients with resected American Joint Committee on Cancer Stage IIC, IIIA, and IIIB cutaneous melanoma received nonpegylated IFN α-2b 20 million units/m(2) /day intravenously 5 days per week for 4 weeks (induction) followed by pegylated IFN α-2b 1 μg/kg/dose weekly subcutaneously (SQ) for 48 weeks (maintenance). Twenty-three patients (15 females, median age 10 years) were enrolled. All patients completed induction therapy; five patients did not complete maintenance therapy either because of recurrent disease (n = 2) or toxicity (n = 3). The most common grade 3 and 4 toxicities of pegylated IFN α-2b were neutropenia (35%) and elevated liver transaminases (17%). The median nonpegylated IFN α-2b AUC0-∞ (5,026 pcg⋅hr/ml) was similar to adults. The median pegylated IFN α-2b exposure (48,480 pcg⋅hr/ml) was greater than th...Continue Reading

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Citations

Jul 4, 2018·Pediatric Blood & Cancer·Alice IndiniAndrea Ferrari
Apr 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·C StefanakiA Stratigos
Jul 4, 2020·Current Opinion in Pediatrics·Danna MoustafaElena B Hawryluk
Jun 28, 2018·Paediatric Drugs·Mary Frances WedekindTimothy P Cripe
Mar 30, 2019·Paediatric Drugs·Haya S RaefElena B Hawryluk
Aug 21, 2018·Pediatric Blood & Cancer·Hadeel HalalshehAlberto Pappo
Mar 17, 2020·Current Hematologic Malignancy Reports·Nicole Kucine
Mar 13, 2021·Surgical Oncology Clinics of North America·Jennifer H AldrinkMary Austin

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