Feasibility of Preoperative Chemotherapy With or Without Radiation Therapy in Localized Soft Tissue Sarcomas of Limbs and Superficial Trunk in the Italian Sarcoma Group/Grupo Español de Investigación en Sarcomas Randomized Clinical Trial: Three Versus Five Cycles of Full-Dose Epirubicin Plus Ifosfamide

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
E PalassiniA Gronchi

Abstract

We report on feasibility of preoperative chemotherapy with or without radiation therapy (RT) in the context of a phase III randomized clinical trial involving localized, high-risk, soft tissue sarcomas. Of 321 eligible patients, 161 were randomly assigned to three preoperative cycles of epirubicin 120 mg/m(2) plus ifosfamide 9 g/m(2), and 160 were randomly assigned to three preoperative plus two postoperative cycles. Among them, 303 patients were included in this analysis; 169 were male and 134 were female, with a median age of 48 years (range, 15 to 79 years). One hundred fifty-two patients received concurrent RT preoperatively at a total dose of 44 to 50 Gy. Preoperative chemotherapy-related hematologic toxicity and early postoperative complications were reported. The influence of RT, age, and sex on hematologic grade 3 or 4 toxicities and wound complications was analyzed. Chemotherapeutic dose intensity (DI) was analyzed. Among the patients, 61.4%, 22.4%, and 23.8% experienced, grade 4 leucopenia, grade 3 or 4 anemia, and grade 3 or 4 thrombocytopenia, respectively. Respective rates were 66.4%, 24.3%, and 31.6% when RT was added preoperatively, and 56.3%, 20.5%, and 15.9% when preoperative chemotherapy was administered alone...Continue Reading

References

Feb 11, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L LongoV T DeVita
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C YangS A Rosenberg
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D CrivellariA Goldhirsch
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S FrustaciP Picci
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyDavid C Harmon
Feb 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William G KraybillUNKNOWN Radiation Therapy Oncology Group Trial 9514
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard M GoldbergDaniel J Sargent
Sep 15, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T E PavlidisA Sakantamis
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmela PepeUNKNOWN National Cancer Institute of Canada and Intergroup Study JBR.10
May 15, 2009·The New England Journal of Medicine·Hyman B MussUNKNOWN CALGB Investigators
Nov 12, 2009·Journal of Cancer Research and Clinical Oncology·James CassidyUlrich-Peter Rohr
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Ali Al YamiBrian O'Sullivan
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy J DavidoffMartin J Edelman
Apr 1, 2010·Annals of Surgical Oncology·Waddah B Al-RefaieBeth A Virnig
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro GronchiPiero Picci
Sep 8, 2012·The Lancet Oncology·Penella J WollUNKNOWN EORTC Soft Tissue and Bone Sarcoma Group and the NCIC Clinical Trials Group Sarcoma Disease Site Committee
Oct 25, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nicole J Look HongJohn T Mullen
Nov 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GronchiP G Casali
Jan 17, 2013·Cancer Investigation·Igor MatushanskyAlfred I Neugut
Mar 6, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas AparicioEmmanuel Mitry
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN ESMO/European Sarcoma Network Working Group

❮ Previous
Next ❯

Citations

Apr 21, 2017·Current Opinion in Oncology·Sandro PasqualiAlessandro Gronchi
Nov 28, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Yves BlayIsabelle Ray-Coquard
May 17, 2018·Future Oncology·Jean-Yves Blay
Apr 14, 2017·The Cochrane Database of Systematic Reviews·Frank PeinemannLesley A Smith
Oct 10, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sebastian ZschaeckPirus Ghadjar
Dec 9, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rick L HaasAxel Le Cesne
May 19, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alessandro GronchiPaolo Giovanni Casali
May 29, 2020·Current Treatment Options in Oncology·Gaya SpolveratoAlessandro Gronchi
Jul 29, 2020·Annals of Surgical Oncology·Christina L RolandAlessandro Gronchi
Jul 28, 2016·Current Opinion in Oncology·Rolf Issels, Lars H Lindner
Jun 14, 2017·Therapeutic Advances in Medical Oncology·Sandro Pasquali, Alessandro Gronchi
Nov 29, 2016·Clinical Sarcoma Research·Adam DangoorIan Judson
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Elizabeth H BaldiniJonathan C Trent
Jul 30, 2020·Cancers·Mateusz Jacek SpałekPiotr Rutkowski
May 2, 2020·World Journal of Clinical Oncology·Jorge Gómez, Panagiotis Tsagozis
Nov 14, 2018·Annals of Surgical Oncology·Marco Fiore, Alessandro Gronchi
May 7, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Silvia CammelliAlessio G Morganti
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P G CasaliUNKNOWN ESMO Guidelines Committee and EURACAN. Electronic address: clinicalguidelines@esmo.org
Jul 26, 2021·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GronchiUNKNOWN ESMO Guidelines Committee, EURACAN and GENTURIS. Electronic address: clinicalguidelines@esmo.org

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.