Feasibility of re-biopsy and EGFR mutation analysis in patients with non-small cell lung cancer

Thoracic Cancer
Tae-Ok KimYoo-Duk Choi

Abstract

In cases of EGFR-tyrosine kinase inhibitor (TKI) failure, re-biopsy may be useful to understand resistance mechanisms and guide further treatment decisions. However, performing re-biopsy is challenging because of several hurdles. We assessed the feasibility of re-biopsy in advanced non-small cell lung cancer (NSCLC) patients in real-world clinical practice. We retrospectively reviewed the clinical and pathologic data of advanced NSCLC patients who experienced disease progression after previous treatment with EGFR-TKIs at a single tertiary hospital in Korea between January 2014 and December 2016. Re-biopsy specimens included small biopsy, surgical tissue, or liquid-based cytology. EGFR mutation was tested using peptide nucleic acid-mediated clamping PCR. Of the 230 NSCLC patients that experienced progression after EGFR-TKI therapy, 105 (45.7%) underwent re-biopsy. Re-biopsy was successfully performed in 94 (89.5%) patients, and 11 patients were diagnosed with no malignancy. The complication rate was 8.6%, including seven cases of pneumothorax. EGFR mutation testing was performed on 75 patients using re-biopsy specimens. Of the 57 patients who had sensitizing mutations at diagnosis, T790M mutations were found in 19 (33.3%), while...Continue Reading

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Citations

Aug 31, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Mariano ProvencioAtocha Romero
Nov 16, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Jianyuan ZhangJingya Han
Mar 14, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J GaoJ-Y Ding

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Methods Mentioned

BETA
PCR
biopsy
genotyping

Software Mentioned

SPSS

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