Feasibility of Selective Neck Irradiation with Lower Elective Radiation Dose in Treating Nasopharynx Cancer Patients

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Won Kyung ChoYong Chan Ahn

Abstract

This study aimed to report the clinical outcomes following selective neck irradiation (SNI) with lower elective radiation therapy (RT) dose in treating nasopharyngeal cancer (NPC) patients. A total of 347 NPC patients received definitive RT according to our SNI policy and were retrospectively analyzed. The clinical target volumes (CTVs) were subdivided into CTV at high risk (CTV-HR) and CTV at low risk (CTV-LR). The typical doses to gross tumor volume (GTV), CTV-HR, and CTV-LR were 68.4-70.0 Gy, 54.0-60.0 Gy, and 36.0 Gy. With the median follow-up of 68.1 months (range, 2.3 to 197.1 months), the 5-year rates of loco-regional control and progression-free survival in all the patients were 85.0% and 70.8%, respectively. Thirty patients developed regional failure and the regional control rates at 3 and 5 years were 92.6% and 91.4%, respectively. The sites of regional failure in relation to the target volume were exclusively inside GTV/CTV-HR in 20, inside and outside GTV/CTVHR in three, and exclusively outside GTV/CTV-HR in seven, which were 5.7%, 0.9%, and 2.0% of total patients, respectively. The clinical outcomes by the current SNI policy were feasible and comparable to those following classic elective nodal irradiation policy.

References

Jan 15, 1995·International Journal of Radiation Oncology, Biology, Physics·H R WithersJ M Taylor
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Suzanne L WoldenMichael J Zelefsky
Oct 25, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S-H I OuH Anton-Culver
Aug 4, 2009·International Journal of Radiation Oncology, Biology, Physics·Frank C S WongStewart Y Tung
Jan 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Yunsheng GaoChaosu Hu
Mar 6, 2012·International Journal of Radiation Oncology, Biology, Physics·Edmond H N PowSherry C Y Ng
Apr 21, 2012·International Journal of Radiation Oncology, Biology, Physics·Meena BediDian Wang
Nov 15, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard L GundersonChristopher G Willett
Dec 21, 2012·AJR. American Journal of Roentgenology·Jenny K HoangChristine M Glastonbury
Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sandra NuytsWilfried De Neve
Mar 15, 2016·International Journal of Radiation Oncology, Biology, Physics·Sven van den BoschJohannes H A M Kaanders
Aug 17, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daan NevensSandra Nuyts
Aug 22, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter G HawkinsAvraham Eisbruch
Nov 21, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne W LeeJoseph T Wee
Feb 18, 2018·International Journal of Radiation Oncology, Biology, Physics·Patrick D MaguireAndrew M Schreiber
May 8, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sven van den BoschJohannes H A M Kaanders

❮ Previous
Next ❯

Citations

Sep 25, 2020·International Journal of Radiation Oncology, Biology, Physics·Wen-Shan LiuYaoh-Shiang Lin
May 4, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes H A M KaandersWouter V Vogel
Mar 30, 2021·Head & Neck·Wai Tong NgAlfio Ferlito
Dec 8, 2020·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Ji-Jin YaoYing Sun
Mar 31, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Heerim NamJae Myoung Noh
Mar 31, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Donghyeok KimYong Chan Ahn

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.