Feasibility of sentinel node detection in renal cell carcinoma: a pilot study.

European Journal of Nuclear Medicine and Molecular Imaging
Axel BexRenato A Valdés Olmos

Abstract

Lymphatic drainage from renal cell carcinoma is unpredictable and the therapeutic benefit and extent of lymph node dissection are controversial. We evaluated the feasibility of intratumoural injection of a radiolabelled tracer to image and sample draining lymph nodes in clinically non-metastatic renal cell carcinoma. Eight patients with cT1-2 cN0 cM0 (<6 cm) renal cell carcinoma prospectively received percutaneous intratumoural injections of (99m)Tc-nanocolloid under ultrasound guidance (0.4 ml, 225 MBq at one to four intratumoural locations depending on tumour size). Lymphoscintigraphy was performed 20 min, 2 h and 4 h after injection. After the delayed images a hybrid SPECT/CT was performed. SPECT was fused with CT to determine the anatomical localization of the sentinel node. Surgery with sampling was performed the following day using a gamma probe and a portable mini gamma camera. Eight patients, seven with right-sided renal cell carcinoma, were included with a mean age of 55 years (range: 45-77). The mean tumour size was 4 cm (range: 3.5-6 cm). Six patients had sentinel nodes on scintigraphy (two retrocaval, four interaortocaval, including one hilar) with one extraretroperitoneal location along the internal mammary chain. ...Continue Reading

References

Sep 1, 1992·European Journal of Radiology·T G Mahon, H I Libshitz
Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jun 1, 1982·The Journal of Urology·H SaitohT Satoh
Oct 1, 1982·The Journal of Urology·F F Marshall, K C Powell
Feb 1, 1997·The Journal of Urology·J A Johnsen, S Hellsten
Mar 20, 2002·The Annals of Thoracic Surgery·Marc RiquetGeneviève Hidden
Mar 5, 2003·BJU International·C TerroneS Rocca Rossetti
May 29, 2003·The Journal of Urology·Allan J PantuckArie S Belldegrun
Jun 21, 2003·Journal of Endourology·Jonathan E BernieManoj Monga
Jul 24, 2004·Urologic Oncology·Courtney K Phillips, Samir S Taneja
Mar 15, 2005·Scandinavian Journal of Urology and Nephrology·Hideyasu MatsuyamaKatsusuke Naito
Nov 23, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jalal AssouadClaire Danel
Feb 3, 2009·Annals of Surgical Oncology·Iris M C van der PloegOmgo E Nieweg
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lenka VermeerenSimon Horenblas

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Citations

Feb 26, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Joan Duch
Apr 28, 2011·International Journal of Clinical Oncology·Brian F ChapinChristopher G Wood
Dec 25, 2013·Lymphatic Research and Biology·Oscar R BrouwerAxel Bex
Feb 9, 2012·International Journal of Surgical Oncology·Joseph Edmund Jamal, Thomas William Jarrett
May 9, 2013·Archives of Pathology & Laboratory Medicine·Vikas MehtaMaria M Picken
Sep 24, 2011·European Urology·Umberto CapitanioHein Van Poppel
Nov 3, 2011·The Urologic Clinics of North America·Victoria Chernyak
May 21, 2014·BJU International·Riaz J KarmaliJose A Karam
Sep 1, 2015·Lancet·Umberto Capitanio, Francesco Montorsi
Jul 2, 2016·World Journal of Urology·Umberto Capitanio, Bradley C Leibovich
Oct 16, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·O R BrouwerS Horenblas
Mar 17, 2016·World Journal of Nephrology·Tharani MahesanNick Watkin
Nov 2, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Hermann HertelPeter Hillemanns
Jun 5, 2016·Current Opinion in Urology·Marco MoschiniUmberto Capitanio
Dec 31, 2010·Current Opinion in Urology·Pascal Zehnder, Mihir Desai

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