Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal

The Journal of Headache and Pain
Mi Ji LeeChin-Sang Chung

Abstract

Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chronic migraine. We prospectively recruited patients with episodic and chronic migraine and normal controls (NCs) in the Samsung Medical Center between August 2015 and May 2016. Blood samples were collected interictally from antecubital veins per prespecified protocol. Serum CGRP measurement was performed in the central laboratory by a single experienced technician blinded to clinical information. Migraine subtype, headache days in the previous month, and the presence and characteristics of headache at ±2 days of measurement were evaluated at every visit. A total of 156 migraineurs (106 episodic and 50 chronic) and 27 NCs were recruited in this study. Compared to NCs (75.7 ± 20.07 pg/mL) and patients with episodic migraine (67.0 ± 20.70 pg/mL), patients with chronic migraine did not show an interictal elevation of serum CGRP levels (64.9 ± 15.32 pg/mL). Serum CGRP concentration was not associated with headache status (ictal vs. interictal), migraine subtype (migraine with vs. without aura), use of preventive or acute medicati...Continue Reading

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Citations

May 18, 2019·The Journal of Headache and Pain·Willem Sebastiaan van Hoogstraten, Antoinette MaassenVanDenBrink
Jun 22, 2019·Expert Review of Clinical Pharmacology·Luana LionettoPaolo Martelletti
Jul 22, 2020·Cephalalgia : an International Journal of Headache·Håkan AshinaHenrik Winther Schytz
Jun 11, 2019·Pharmacological Reports : PR·Agnieszka PiechalDagmara Mirowska-Guzel
Oct 12, 2019·Cephalalgia : an International Journal of Headache·Katharina KammRuth Ruscheweyh
Aug 28, 2020·Cephalalgia : an International Journal of Headache·Katharina KammRuth Ruscheweyh
Dec 4, 2020·Cephalalgia : an International Journal of Headache·Pablo IrimiaRogelio Leira
Dec 8, 2020·Pain Management·María Dolores Villar-MartínezPeter J Goadsby
Dec 10, 2020·Cephalalgia : an International Journal of Headache·Patricia Pozo-RosichTodd J Schwedt
Mar 29, 2021·Lancet·Messoud AshinaPeter J Goadsby
Apr 29, 2021·Journal of Pain Research·Sui-Yi XuChang-Xin Li
May 3, 2021·Annals of Clinical and Translational Neurology·Bianca RaffaelliUwe Reuter
Jul 17, 2021·Cephalalgia : an International Journal of Headache·Karl MesslingerGregor Broessner
Jul 3, 2021·Expert Review of Neurotherapeutics·Karen Santos FerreiraAna Miriam Velly
Sep 29, 2019·ACS Pharmacology & Translational Science·Andrew F Russo
Oct 5, 2021·Cephalalgia : an International Journal of Headache·Alicia AlpuentePatricia Pozo-Rosich
Oct 5, 2021·Cephalalgia : an International Journal of Headache·Karl Messlinger
Jan 12, 2022·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Simona GuerzoniLuca Pani

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