Feasibility of Short-Term PrEP Uptake for Men Who Have Sex With Men With Episodic Periods of Increased HIV Risk.

Journal of Acquired Immune Deficiency Syndromes : JAIDS
James E EganKenneth H Mayer

Abstract

Pre-exposure prophylaxis (PrEP) with emtricitabine/tenofovir disoproxil fumarate is efficacious in reducing HIV acquisition. For some gay, bisexual, and other men who have sex with men (MSM), daily ongoing PrEP may be unsuitable for use as a long-term prevention strategy because of episodic risk, cost issues, or concerns about the biological consequences of medication. This study evaluated the feasibility of short-term, fixed-interval episodic PrEP (Epi-PrEP) for use among vacationing MSM. We describe the feasibility of implementing a clinic-based Epi-PrEP pilot program for 48 MSM who reported occasional condomless sex and anticipated a defined high-risk time. This was a nonrandomized naturalistic study of an observational clinical intervention. The primary outcome assessed was adherence, as measured by self-report and plasma tenofovir levels. Of 54 MSM who enrolled in the study, 48 completed the 3-month visit. The majority (93.7%) had tenofovir concentrations consistent with daily use on returning from vacation. Almost 3/4 reported condomless sex during vacation, and about 1/3 reported recreational drug use. During the 3-month follow-up, 1 participant had become HIV-infected because of a lapse in continued access to the PrEP a...Continue Reading

References

Nov 15, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·G N ColfaxS Buchbinder
Nov 26, 2010·The New England Journal of Medicine·Robert M GrantUNKNOWN iPrEx Study Team
Sep 14, 2012·Science Translational Medicine·Peter L AndersonUNKNOWN iPrEx Study Team
Nov 29, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jianmeng ChenEdward J Fuchs
Apr 23, 2013·AIDS Research and Human Retroviruses·Nicolette A LouissaintCraig W Hendrix
Sep 16, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Conor StackKenneth H Mayer
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Feb 12, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey T ParsonsChristian Grov
Jul 15, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte-Paige RolleColleen F Kelley
Oct 31, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kenneth H MayerDouglas S Krakower
Feb 9, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert M GrantTimothy H Holtz
Mar 28, 2018·JAMA : the Journal of the American Medical Association·James RiddellKenneth H Mayer
Mar 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sharon MannheimerRobert M Grant
Apr 10, 2019·JAMA : the Journal of the American Medical Association·Michael W TraegerUNKNOWN PrEPX Study Team
Aug 31, 2019·AIDS and Behavior·Charlotte-Paige RolleDavid P Holland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.