Feasibility of simultaneous PET-MR perfusion using a novel cardiac perfusion phantom

European Journal of Hybrid Imaging
Jim O' DohertyAmedeo Chiribiri

Abstract

PET-MR scanners are beginning to be employed for quantitative myocardial perfusion imaging. In order to examine simultaneous perfusion calculations, this work describes a feasibility study of simultaneous PET-MR of gadolinium-based contrast agent (GBCA) and PET radiotracer in a novel cardiac perfusion phantom. [18F]F- and GBCA were injected simultaneously into a cardiac phantom using a range of ground-truth myocardial perfusion rates of 1 to 5 ml/g/min. PET quantification of K 1 (ml/g/min) was performed using a single tissue compartment model. MR perfusion was calculated using a model-independent signal deconvolution technique. PET and MR signal traces from the phantom aorta and myocardial sections show true simultaneous PET and MR arterial input functions (AIF) and myocardial uptake respectively at each perfusion rate. Calculation of perfusion parameters showed both K 1 and h(t = 0) (PET and MR perfusion parameters respectively) to be linearly related with the ground truth perfusion rate (P T ), and also linearly related to each other (R2 = 0.99). The highest difference in perfusion values between K 1 and P T was 16% at 1 ml/g/min, and the mean difference for all other perfusion rates was <3%. The perfusion phantom allows...Continue Reading

References

May 4, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marcelo F Di CarliStephen C Moore
Mar 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Axel Martinez-MöllerStephan G Nekolla
Jun 27, 2009·Journal of the American College of Cardiology·Frank M BengelRiikka Lautamäki
Aug 7, 2010·Journal of the American College of Cardiology·Amit R PatelChristopher M Kramer
Oct 12, 2010·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Michael Jerosch-Herold
May 26, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Masaki IshidaEike Nagel
Feb 23, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Niloufar ZarinabadEike Nagel
Apr 26, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amedeo ChiribiriEike Nagel
May 12, 2012·IEEE Transactions on Bio-medical Engineering·Gilion HautvastEike Nagel
Nov 28, 2012·Seminars in Nuclear Medicine·Jinsong OuyangGeorges El Fakhri
Feb 14, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christoph RischplerMarkus Schwaiger
Apr 30, 2013·Journal of Cardiovascular Computed Tomography·James OttonAmedeo Chiribiri
May 9, 2013·Radiology·Felix NensaThomas Schlosser
Apr 26, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Osman Ratib, René Nkoulou
Sep 4, 2014·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Felix Nensa, Thomas Schlosser
Jan 2, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Felix NensaKai Nassenstein
Mar 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Abolfazl Mehranian, Habib Zaidi
Apr 7, 2015·Seminars in Nuclear Medicine·Christoph RischplerMarkus Schwaiger
Jun 21, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Jan VontobelPhilipp A Kaufmann
Aug 20, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jennifer M RenaudRobert A deKemp
Jan 1, 2017·European Journal of Hybrid Imaging·Jim O'DohertyAmedeo Chiribiri

❮ Previous
Next ❯

Citations

May 20, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xenios MilidonisAmedeo Chiribiri
Mar 5, 2020·European Radiology Experimental·Marije E KamphuisCornelis H Slump
Jan 1, 2017·European Journal of Hybrid Imaging·Jim O'DohertyAmedeo Chiribiri
Aug 27, 2021·EJNMMI Physics·Eve LennieSteven Sourbron

❮ Previous
Next ❯

Methods Mentioned

BETA
saturation recovery gradient

Software Mentioned

OsiriX
LabVIEW System
house
LabVIEW
REPEAT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.