Feasibility of stereotactic radiotherapy for lung lesions and conventional radiotherapy for nodal areas in primary lung malignancies

Radiation Oncology
Yeon Joo KimEun Kyung Choi

Abstract

Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer. This study included 21 patients with small primary lung tumors distant from the regional nodal areas. The SBRT dose was 40-60 Gy in 4 fractions. CRT doses were 66 Gy in 30 fractions for non-small cell lung cancer and 52.5 Gy in 25 fractions for small cell lung cancer. The median follow-up duration was 12 months, and the median survival was 13 months. The 1 year overall survival, local recurrence-free survival, and distant metastasis-free survival rates were 60.5, 84.8, and 62.1%, respectively. Two patients experienced in-field local recurrence combined with out-field regional recurrence and/or distant failure. The major recurrence pattern was distant failure (crude incidence, 43%). Three patients aged ≥79 years experienced grade ≥ 3 acute radiation pneumonitis, and one also had idiopathic interstitial pneumonia. The combination of SBRT for the lung lesion and CRT for the nodal region seems to be effective and safe for lung malignancies. However, patients older in age and/or with underlying pulmonary disease require stricter lung do...Continue Reading

References

Jun 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P Warde, D Payne
Nov 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P Pignon, R Arriagada
Apr 28, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Line ClaudeChristian Carrie
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierre FournelUNKNOWN Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Français de Pneumo-Cancérologie
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rudolf M HuberUNKNOWN Bronchial Carcinoma Therapy Group
Dec 20, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Frances A ShepherdUNKNOWN International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions
Oct 22, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hekun JinZhongxing Liao
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Dec 26, 2012·International Journal of Radiation Oncology, Biology, Physics·Jonathan FeddockRonald C McGarry
Jan 5, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Cliff G RobinsonJeffrey D Bradley
Jul 15, 2015·Radiation Oncology Journal·In-Hye JungEun Kyung Choi
Feb 24, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Judi N A van DiessenJan-Jakob Sonke
Apr 23, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arturo Navarro-MartinFerran Guedea
Aug 9, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ilinca PoppDan G Duda
Oct 27, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jan NymanIngmar Lax

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