PMID: 6990235Apr 1, 1980Paper

Feasibility of testing DNA repair inhibitors for mutagenicity by a simple method

Mutation Research
A S SideropoulosM T Jones

Abstract

A simple screening methodology for the determination of mutagenicity of DNA repair inhibitors has been tested in this laboratory. Radiation-resistant E. coli B/r and WP2 hcr+ and hcr- are suitable strains for mutagenicity testing. In these strains irradiated with 40-60 ergs/mm2, chemicals which interfere with repair of ultraviolet-induced pre-mutational lesions can be shown to enhance significantly the frequency of mutations to streptomycin resistance. This phenomenon is termed "mutational synergism" [18,20]. We have attempted to apply the procedure for securing data for "mutational synergism" between ultraviolet (UV) radiation and a number of antimalarial drugs including quinine hydrochloride (50 microgram/ml), quinine hydrobromide (50 microgram/ml), primaquine diphosphate (50 microgram/ml), chloroquine (50 microgram/ml), quinine (50 microgram/ml) and quinacrine dihydrochloride (25 microgram/ml). All drugs tested give synergistic effects with UV light. The synergistic activity ranges from 3- to 35-fold. Quinine and quinacrine dihydrochloride have been found to be much more efficient enhancers of the mutagenic effect of UV than caffeine. In general, we have found that the expression of synergistic action occurs at a concentrati...Continue Reading

References

Feb 1, 1976·Mutation Research·M H Green, W J Muriel
Dec 1, 1976·Environmental Research·I B Rubin, M R Guerin
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B N AmesE Yamasaki
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L D KierB N Ames
Jan 1, 1968·Molecular & General Genetics : MGG·A S SideropoulosD M Shankel
May 5, 1967·Science·J Ciak, F E Hahn
Feb 1, 1961·Journal of Molecular Biology·L S LERMAN
Feb 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·R B SETLOW, W L CARRIER
Aug 1, 1964·Journal of Molecular Biology·D PETTIJOHN, P HANAWALT

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Citations

Jan 22, 1998·Mutation Research·J B BishopR A Sloane
Mar 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Renata C Ferreira, Marcelo R S Briones
Jun 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W Burkhard, H Fritz-Niggli
Sep 5, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Allan GiriAshok K Giri

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