Feasibility of the single-bolus strategy for measuring the partition coefficient of Gd-DTPA in patients with myocardial infarction: independence of image delay time and maturity of scar

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
R E ThornhillAnya Sauer

Abstract

The partition coefficient of Gd-DTPA (lambda) is elevated in infarcted relative to normal myocardium. Although MRI following an infusion of Gd-DTPA allows for the quantification of lambda, infarct imaging is more routinely performed using a bolus. In this study we sought to determine how image delay time and time postinfarction influence the estimation of lambda by the bolus strategy. Both infusion and bolus imaging were performed twice in the same group of patients (N = 9): once at 3-4 weeks and again 6 months after reperfusion therapy for myocardial infarction (MI). Bolus estimates of lambda were compared with those calculated after 60 min infusion, and comparisons were repeated at 6 months. The lambda of infarcted myocardium was significantly greater than that of normal tissue, irrespective of either the technique used or the time postinfarction (P < 0.0001, for each). The concordance (Rc) between bolus and infusion estimates of lambda was >0.83 for all image delays >4 min postinjection, and Rc at 2 min (0.78 +/- 0.04) was significantly less than Rc determined for longer image delay times (P = 0.009). Rc did not change with time postinfarction (P = 0.604). Thus, the bolus strategy can be used to provide estimates of lambda t...Continue Reading

References

Feb 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L D DiesbourgB O'Neill
Jan 1, 1986·Journal of the American College of Cardiology·B I Jugdutt, R W Amy
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Y TongJ Wills
Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S PereiraG Wisenberg
Aug 5, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S PereiraG Wisenberg
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R E ThornhillJ Sykes
Sep 18, 2002·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rebecca E ThornhillGerald Wisenberg
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G R MoranF S Prato
May 13, 2004·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Steffen E PetersenKarl-Friedrich Kreitner
May 13, 2004·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Maria AnsariDavid A Saloner
Jun 15, 2004·Journal of the American College of Cardiology·W Patricia IngkanisornAndrew E Arai
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rebecca E ThornhillJane Sykes
Dec 21, 2004·Journal of the American College of Cardiology·Luciano C AmadoJoão A C Lima
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanAndrew E Arai

❮ Previous
Next ❯

Citations

Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael Jerosch-HeroldRay E Hershberger
Apr 29, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Gerald WisenbergFrank S Prato
Mar 8, 2011·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Erik B SchelbertTimothy C Wong
May 1, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nadine KawelDavid A Bluemke
Dec 11, 2007·Magnetic Resonance Imaging·Nathan A PackChristopher J McGann
Sep 15, 2012·JACC. Cardiovascular Imaging·François-Pierre MongeonRaymond Y Kwong
Jun 18, 2017·The International Journal of Cardiovascular Imaging·Nadya Al-Wakeel-MarquardDaniel R Messroghli
Dec 5, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B WilkF S Prato
Jan 20, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·B WilkF S Prato
Jan 28, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·H SmailovicF S Prato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.