Feasibility of treating prehypertension with an angiotensin-receptor blocker

The New England Journal of Medicine
Stevo JuliusTrial of Preventing Hypertension (TROPHY) Study Investigators

Abstract

Prehypertension is considered a precursor of stage 1 hypertension and a predictor of excessive cardiovascular risk. We investigated whether pharmacologic treatment of prehypertension prevents or postpones stage 1 hypertension. Participants with repeated measurements of systolic pressure of 130 to 139 mm Hg and diastolic pressure of 89 mm Hg or lower, or systolic pressure of 139 mm Hg or lower and diastolic pressure of 85 to 89 mm Hg, were randomly assigned to receive two years of candesartan (Atacand, AstraZeneca) or placebo, followed by two years of placebo for all. When a participant reached the study end point of stage 1 hypertension, treatment with antihypertensive agents was initiated. Both the candesartan group and the placebo group were instructed to make changes in lifestyle to reduce blood pressure throughout the trial. A total of 409 participants were randomly assigned to candesartan, and 400 to placebo. Data on 772 participants (391 in the candesartan group and 381 in the placebo group; mean age, 48.5 years; 59.6 percent men) were available for analysis. During the first two years, hypertension developed in 154 participants in the placebo group and 53 of those in the candesartan group (relative risk reduction, 66.3 p...Continue Reading

References

Feb 24, 1977·The New England Journal of Medicine·M EslerV DeQuattro
Aug 1, 1992·American Heart Journal·J M NeutelM A Weber
Jan 1, 1991·Journal of Hypertension·S JuliusJ Petrin
Jul 18, 1991·The American Journal of Medicine·M A WeberW F Graettinger
Jul 18, 1990·JAMA : the Journal of the American Medical Association·S JuliusK Jones
Sep 1, 1987·The Journal of Clinical Investigation·B EganS Julius
Mar 1, 1971·Journal of Chronic Diseases·S Julius, M A Schork
Apr 1, 1982·Physiological Reviews·B Folkow
Aug 11, 1993·JAMA : the Journal of the American Medical Association·J D NeatonR McDonald
Jan 17, 2002·The New England Journal of Medicine·R S VasanD Levy
Oct 17, 2002·JAMA : the Journal of the American Medical Association·Paul K WheltonUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Apr 24, 2003·JAMA : the Journal of the American Medical Association·Lawrence J AppelUNKNOWN Writing Group of the PREMIER Collaborative Research Group
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Jul 9, 2004·Hypertension·Stevo JuliusUNKNOWN TROPHY study group
Jul 28, 2005·Annals of Family Medicine·Heather A LiszkaBrent M Egan
Aug 2, 2005·American Journal of Hypertension·Shawna D NesbittUNKNOWN TROPHY Study Investigators
Aug 6, 2005·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiYousef Mohammad

❮ Previous
Next ❯

Citations

Aug 24, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mieczyslaw LitwinJanusz Feber
May 11, 2010·Cardiovascular Drugs and Therapy·Jay N Cohn
May 13, 2011·Prevention Science : the Official Journal of the Society for Prevention Research·Rui Wang, James H Ware
Jan 30, 2008·Medical & Biological Engineering & Computing·Michael J Mulvany
Dec 17, 2008·Current Atherosclerosis Reports·Jennifer G Robinson
Nov 8, 2006·Current Hypertension Reports·Keith C Ferdinand, Myra A Kleinpeter
Sep 13, 2006·Current Hypertension Reports·Nitin Khosla, Henry R Black
May 24, 2007·Current Hypertension Reports·Stevo Julius
Aug 10, 2007·Current Hypertension Reports·Helmy M Siragy
Aug 10, 2007·Current Hypertension Reports·Joseph L Izzo
Jan 8, 2008·Current Hypertension Reports·William C Cushman
Jul 16, 2008·Current Hypertension Reports·Norman M Kaplan
Sep 9, 2008·Current Hypertension Reports·Brent M Egan, Stevo Julius
Jan 17, 2009·Current Hypertension Reports·Sandra J Taler
Apr 3, 2012·Current Hypertension Reports·Vadim Tchaikovski, Gregory Y H Lip
Aug 11, 2012·Current Hypertension Reports·Karen M Redwine, Bonita Falkner
Sep 21, 2013·Current Hypertension Reports·Keith M Diaz, Daichi Shimbo
Oct 22, 2013·Current Hypertension Reports·Brent M Egan, Marilyn A Laken
Jul 24, 2008·Current Treatment Options in Cardiovascular Medicine·Ross PaciniLaurence S Sperling
Oct 13, 2006·Current Treatment Options in Neurology·Laura Pedelty, Philip B Gorelick
Jan 10, 2012·Journal of Cardiovascular Translational Research·Hirofumi Tomiyama, Akira Yamashina
Dec 24, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R P DonahueM Trevisan
May 31, 2007·The Canadian Journal of Cardiology·UNKNOWN Canadian Hypertension Education Program
Sep 4, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaki Mogi, Masatsugu Horiuchi
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jun IwanamiMasatsugu Horiuchi
Jun 13, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroyuki SasamuraHiroshi Itoh
Jun 23, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro KatsuyaToshio Ogihrara
May 14, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro Katsuya, Ryuichi Morishita
Dec 2, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuhiko TogashiTetsuji Miura
Jan 20, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroyuki Sasamura, Hiroshi Itoh
Feb 5, 2009·Journal of Human Hypertension·G ManciaG Grassi
Jul 11, 2008·Journal of Human Hypertension·S S Franklin, J M Neutel
Mar 16, 2012·Journal of Human Hypertension·C SabanayagamE S Tai
Mar 29, 2013·Journal of Human Hypertension·E B LevitanP Muntner
Sep 26, 2007·Nature Clinical Practice. Cardiovascular Medicine·William J Elliott, Henry R Black
Sep 27, 2007·Nature Clinical Practice. Nephrology·Branko BraamJaap A Joles
Nov 18, 2009·Nature Reviews. Nephrology·Eduardo Pimenta, Suzanne Oparil
Dec 22, 2009·Nature Reviews. Nephrology·Luis M Ruilope
Jun 22, 2007·Journal of Human Hypertension·L B MoreiraF D Fuchs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antipsychotic-Induced Weight Gain

Antipsychotic-induced weight gain (aiwg) is a common adverse effect of this treatment, particularly with second-generation antipsychotics, and it is a major health problem around the world. Here are the latest discoveries pertaining to AIWG.