Feasibility of unilateral parathyroidectomy in patients with primary hyperparathyroidism and negative or discordant localization studies

Updates in Surgery
Pietro Giorgio CalòAngelo Nicolosi

Abstract

The purpose of this study was to examine the feasibility of unilateral parathyroidectomy in patients with primary hyperparathyroidism and negative or discordant localization studies. We included in our study 72 patients with preoperative diagnosis of primary hyperparathyroidism who had negative or discordant preoperative studies. In 66 patients, studies were discordant while in six were both negative. In 40 (55.6 %) patients initial approach was a bilateral exploration. In 32 cases (44.4 %) initial surgery was a unilateral exploration: in 26 conservative approach was successful, in six mini-invasive surgery failed and a bilateral exploration was necessary due to IOPTH negative test (five cases) or to the impossibility to find a pathological gland during exploration (one case). Intra-operative PTH test showed a sensitivity of 93.2 %, a specificity of 92.3 %, and an accuracy of 93.1 %. Multiple gland disease was found in 8 (11.1 %) patients (two double adenoma and six multiple gland hyperplasia). Mean operative time was lower in unilateral exploration group (87.9 ± 43.8 min). Comparing unilateral surgery in negative or discordant studies with 77 consecutive patients who underwent focused surgery with positive and concordant studi...Continue Reading

References

May 25, 2007·Annals of Surgical Oncology·Alysandra Lal, Herbert Chen
Apr 23, 2008·Archives of Surgery·Rodney K ChanFrancis D Moore
Jul 25, 2008·Langenbeck's Archives of Surgery·Celestino Pio LombardiRocco Bellantone
Jun 24, 2009·Langenbeck's Archives of Surgery·Mark ThierJohan Westerdahl
Feb 22, 2012·Archives of Otolaryngology--head & Neck Surgery·Emad KandilRalph P Tufano
Mar 23, 2012·Annals of Surgical Oncology·Benzon M DyClive S Grant
Nov 20, 2013·Clinical Medicine Insights. Case Reports·Pietro Giorgio CalòAngelo Nicolosi
Nov 23, 2013·Annals of Surgery·David F SchneiderRebecca S Sippel

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Citations

Nov 12, 2016·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Arvind KrishnamurthyRamachandran Krishna Kumar
Apr 27, 2017·Updates in Surgery·Giovanni DocimoSalvatore Tolone
Sep 24, 2021·Polski przeglad chirurgiczny·Divya DahiyaArunanshu Behera

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