Abstract
The feasibility of using collagen as the base of miconazole was investigated. The addition of 33% collagen to a miconazole solution did not affect the minimal inhibitory concentration (MIC80) of the miconazole solution for Candida albicans. When 1 microg mL(-1) of miconazole in 33% collagen solution was plated on resin discs and dried to yield a thin membrane, the growth of C. albicans on the resin discs was nearly completely inhibited. In addition, we compared the antifungal effect of this collagen solution that contained 1 microg mL(-1) miconazole, with the antifungal effect of miconazole gel that had been diluted with glycerol (the main component of miconazole gel) to yield a final concentration of 1 microg mL(-1) of miconazole; as a result, we found that the collagen solution containing 1 microg mL(-1) miconazole had a stronger antifungal effect. In conclusion, our results demonstrated that it may be feasible to use collagen as the base of miconazole instead of glycerol, and suggest that a collagen-based miconazole solution would have a stronger antifungal effect than commercially available miconazole gel. Collagen-based miconazole solution may be useful for the treatment of Candida-associated denture stomatitis.
References
Oct 1, 1976·Australian Dental Journal·R J Bastiaan
Apr 1, 1992·Australian Dental Journal·S Jeganathan, C C Lin
Jan 1, 1991·European Journal of Epidemiology·G TronchinJ M Senet
May 1, 1989·Journal of Dental Research·R J Gibbons
Jan 1, 1985·Journal of Inherited Metabolic Disease·I SmithB Kendall
Mar 1, 1970·Acta Odontologica Scandinavica·E Budtz-Jorgensen, U Bertram
Jun 15, 1982·British Dental Journal·C J WatsonR G Newcombe
Mar 1, 1994·Mycoses·E Budtz-Jörgensen, P Carlino
Dec 1, 1994·Scandinavian Journal of Dental Research·T ParvinenA Yli-Urpo
Feb 26, 1998·Mycoses·S ArikanM Akova
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess
Sep 8, 1998·Obesity Surgery
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Jan 5, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Dieter SwatschekJörg Kreuter
Apr 10, 2002·Microbiology and Immunology·Takuji NakashimaHideyo Yamaguchi
Citations
May 29, 2008·Future Microbiology·Andrei Barasch, Andreea Voinea Griffin
Aug 19, 2007·Dental Materials Journal·Takeshi ShibataMinoru Toyoda
Sep 11, 2012·Oral Diseases·C C VillarC-K Yeh
Aug 9, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Oliver AndrewsParvadha Suntharalingam