Abstract
Peritoneal carcinomatosis is common after curative resection of gastric cancer. Intraperitoneal administration of paclitaxel (PTX) is known to control ovarian peritoneal metastases. Patients with either linitis plastica or T4 cancer with high risk of peritoneal metastasis or recurrence but whose cancer was considered resectable were preregistered. After their cancer had been confirmed intraoperatively as resectable, the patients were randomized into either group A (PTX at 60 mg/m(2) intraperitoneally on the day of surgery and on days 14, 21, 28, 42, 49, and 56) or group B (PTX at 80 mg/m(2) administered intravenously by the identical schedule) before being treated by evidence-based chemotherapy. The primary end point was the 2-year survival rate. Safety, the secondary end point, was also analyzed. The study has been registered as UMIN000002957. Of 177 preregistered patients, 83 underwent treatment (39 by intraperitoneal administration and 44 by intravenous administration). There was no difference in patient demographics between the two groups. The incidences of surgical complications were similar between the groups, except for transient bowel obstruction observed exclusively in group A. The relative dose intensity of PTX was 81...Continue Reading
References
Mar 1, 1989·Controlled Clinical Trials·R Simon
Feb 1, 1993·Gynecologic Oncology·R A SegnaC J Cohen
Dec 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FrancisM Markman
Feb 15, 2000·The British Journal of Surgery·C H YooJ S Min
Mar 16, 2000·The British Journal of Surgery·Y MaeharaK Sugimachi
Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Feb 8, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maurie Markman, Joan L Walker
Mar 23, 2006·World Journal of Gastroenterology : WJG·Michiya KobayashiKeijiro Araki
Jun 13, 2006·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Michiya KobayashiJunichi Sakamoto
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
Feb 20, 2008·The Lancet Oncology·Wasaburo KoizumiMasahiro Takeuchi
Mar 21, 2009·Oncology·Hironori IshigamiHirokazu Nagawa
Mar 31, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y KoderaUNKNOWN Chubu Clinical Oncology Group
Jul 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H IshigamiH Nagawa
Jul 30, 2009·Annals of Surgery·Masafumi KuramotoHideo Baba
Oct 16, 2010·Japanese Journal of Clinical Oncology·Yasuhiro KoderaMitsuru Sasako
Feb 22, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Isao MiyashiroUNKNOWN Gastric Cancer Surgical Study Group in the Japan Clinical Oncology Group
Aug 13, 2011·Journal of Surgical Oncology·Motohiro ImanoHitoshi Shiozaki
Feb 13, 2013·Journal of Surgical Oncology·Yoshiaki IwasakiUNKNOWN Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group
Nov 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F RovielloD Marrelli
May 20, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keisuke KurimotoYasuhiro Kodera
Jun 24, 2014·The Lancet Oncology·Akira TsuburayaJunichi Sakamoto
Aug 27, 2014·Journal of the American College of Surgeons·Gaya SpolveratoTimothy M Pawlik
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Nov 19, 2014·Anti-cancer Drugs·Maria Di VitaMassimiliano Berretta
Jul 8, 2015·World Journal of Surgery·Yuichiro MikiMasanori Terashima
Sep 21, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tomohiro NishinaUNKNOWN Gastrointestinal Oncology Study Group of the Japan Clinical Oncology Group
Citations
Dec 8, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Ingo GastingerRoland Croner
Jun 4, 2020·Surgery Today·Sheryl ValenciaMasafumi Nakamura
Jan 14, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Willemieke P M DijksterhuisHanneke W M van Laarhoven
May 7, 2020·Journal of the Egyptian National Cancer Institute·Mohamed Aly AbdelhamedMohamed Shalaby
May 26, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masashi TakeuchiYuko Kitagawa
Sep 22, 2018·Annals of Gastroenterological Surgery·Yasuhiro Kodera
Apr 5, 2019·Journal of Gastric Cancer·Sang-Hoon AhnHyung-Ho Kim
Mar 22, 2020·World Journal of Surgical Oncology·Jinggui ChenYanong Wang
Sep 18, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alex ChenLorenzo Ferri
Mar 15, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Naoto TakahashiYasuhiro Kodera
Sep 20, 2018·F1000Research·Kazuto HaradaJaffer Ajani
Nov 20, 2019·Surgery Today·Shizuki SugitaMasato Nagino
Oct 8, 2020·Journal of Gastric Cancer·Ji-Hyeon ParkHan-Kwang Yang
Dec 3, 2020·British Journal of Cancer·Ziyu LiJiafu Ji
Nov 23, 2020·Tissue & Cell·Xiangwen ZhangGuo Zu
Nov 15, 2020·Journal of Gastrointestinal Cancer·Mohamed M ElmessiryEman A E Mohamed
Mar 17, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yusuke MuneokaSouya Nunobe
Aug 23, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yusuke MuneokaSouya Nunobe
Oct 31, 2019·Annals of Surgery·Tadanobu ShimuraAjay Goel
Nov 28, 2021·Surgery Today·Asami OkamotoYasuyuki Seto