Feasibility study for a randomized clinical trial of bupivacaine, lidocaine with adrenaline, or placebo wound infiltration to reduce postoperative pain after laparoscopic cholecystectomy

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A T AdenekanA O Adisa

Abstract

Short-term pain relief can be achieved by local anaesthetic infiltration of port sites at the end of laparoscopic surgery. This study aimed to assess feasibility of performing an RCT to evaluate short-term postoperative analgesia after laparoscopic surgery in Nigeria using two local anaesthetics for port-site infiltration versus saline placebo. This was a placebo-controlled, patient- and outcome assessor-blinded, external feasibility RCT. Patients undergoing elective laparoscopic cholecystectomy for symptomatic ultrasound-proven gallstones were randomized into three groups: lidocaine with adrenaline (epinephrine), bupivacaine or saline control. The feasibility of recruitment, compliance with randomized treatment allocation, and completion of pain and nausea outcome measures were evaluated. Pain was assessed at 2, 6, 12 and 24 h after surgery using a 0-10-point numerical rating scale (NRS) and a four-point verbal rating scale. Nausea was assessed using NRS at the same time points. Clinical outcomes were assessed only in patients who received the correct randomized treatment allocation. Of 79 patients screened for eligibility, 69 were consented and randomized (23 per group). Overall, compliance with randomized treatment allocatio...Continue Reading

References

Oct 1, 1995·The British Journal of Surgery·F P McGinnM Humby
Aug 6, 1999·BMJ : British Medical Journal·D J Torgerson, C Roberts
Mar 25, 2010·BMJ : British Medical Journal·David MoherDouglas G Altman
Jul 19, 2012·Surgical Endoscopy·Adewale O AdisaOlusegun I Alatise
Aug 22, 2012·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Gerardo Castillo-GarzaOscar Villegas-Cabello
May 4, 2013·The British Journal of Surgery·M H RosenmüllerM M Haapamäki
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Sofronis LoizidesBrian R Davidson
Jul 6, 2017·International Journal of Surgery·Awais RazaUNKNOWN GlobalSurg Collaborative
Dec 21, 2018·The British Journal of Surgery·H HolmerJ Davies
Jan 9, 2019·The British Journal of Surgery·UNKNOWN National Institute for Health Research Global Health Research Unit on Global Surgery

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