Feasibility study into the potential use of fused-deposition modeling to manufacture 3D-printed enteric capsules in compounding pharmacies

International Journal of Pharmaceutics
Christoph NoberJ Goole

Abstract

The purpose of this work was to investigate the feasibility to manufacture enteric capsules, which could be used in compounding pharmacies, by fused-deposition modeling. It is well-known that conventional enteric dip coating of capsules in community pharmacies or hospitals is a time-consuming process which is characterized by an erratic efficacy. Fused-deposition modeling was selected as a potential 3D printing method due its ease and low-cost implementation. Before starting to print the capsules, an effective sealing system was designed via a computer-aided design program. Hot melt extrusion was used to make printable enteric filaments. They were made of the enteric polymer, a plasticizer and a thermoplastic polymer, namely Eudragit® L100-55, polyethylene glycol 400 and polylactic acid, respectively. Riboflavine-5'-phosphate was selected as a coloured drug model to compare the efficacy of the 3D printed capsules to that of enteric dip coated capsules as they are currently produced in community pharmacies and hospitals. Different parameters of fabrication which could influence the dissolution profile of the model drug, such as the layer thickness or post-processing step, were studied. It was demonstrated that our 3D printed ent...Continue Reading

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Citations

Jan 19, 2021·AAPS PharmSciTech·Vanessa Marcia Vaz, Lalit Kumar
Jan 24, 2021·International Journal of Pharmaceutics·Hazal Ezgi GültekinFüsun Acartürk
Feb 28, 2021·International Journal of Pharmaceutics·Yan YangGensheng Yang
Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan
May 25, 2021·Advanced Drug Delivery Reviews·Chloé ParulskiBrigitte Evrard
May 15, 2021·International Journal of Pharmaceutics·Giuseppe ManiniJonathan Goole
Nov 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sylvain CailleauxIan Soulairol
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen
Oct 7, 2021·Drug Delivery and Translational Research·Rabinarayan Parhi, Goutam Kumar Jena

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