Abstract
Early, prehospital cooling seeks to reduce and control the body temperature as early as possible to protect the brain and improve patient outcome in cardiac arrest, stroke, and traumatic brain injury. In this study, we investigate the feasibility of localized cooling of the porcine brain by using a novel high-flow cold air protocol, which utilizes the close proximity between the nasal cavity and the brain. Five adult pigs were anesthetized and temperature change was mapped before, during, and after cooling by using the proton resonance frequency method on a 3 T Siemens Magnetom Skyra system. Cooling was performed by inserting a tube blowing high-flow (250 L/min) cold air (-10°C) through the nasal cavity for 5-20 minutes. The brain temperature change was measured by using an MRI phase mapping technique utilizing the temperature-dependent proton resonance frequency change. MRI maps showed significant temperature reduction of the porcine brain. On average, a mean whole-brain cooling effect of -0.33°C ± 0.30°C was found after 5 minutes of cooling. The anterior part of the brain was directly exposed to the cold and showed a significantly larger temperature drop (-0.83°C ± 0.51°C) than the posterior part (-0.03°C ± 0.21°C). However, ...Continue Reading
References
Mar 5, 2004·The American Journal of Cardiology·David E KandzariRobert M Califf
Sep 9, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·N McDannold
Dec 15, 2005·Critical Care Medicine·Kees H PoldermanArmand R J Girbes
Jan 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Viola Rieke, Kim Butts Pauly
Feb 13, 2008·Neurocritical Care·Marla R WolfsonDenise Barbut
Feb 7, 2009·Journal of Neurotrauma·Hinnerk DollMarc Maegele
Feb 4, 2010·Resuscitation·Daniel HowesMichael Holzer
Aug 4, 2010·Circulation·Maaret CastrénDenise Barbut
Jun 8, 2011·Intensive Care Medicine·L CovaciuS Rubertsson
May 1, 2012·The American Journal of Cardiology·Bryan G SchwartzWilliam J French
Nov 23, 2012·Health Technology Assessment : HTA·B HarrisO Moseley
Dec 20, 2011·Therapeutic Hypothermia and Temperature Management·Shoji YokoboriW Dalton Dietrich
Nov 19, 2013·JAMA : the Journal of the American Medical Association·Francis KimLeonard A Cobb
Jan 9, 2014·Zeitschrift für medizinische Physik·Carsten SiewertHermann Seifert
May 9, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Florian MaierR Jason Stafford
Oct 20, 2015·Resuscitation·Koenraad G MonsieursUNKNOWN ERC Guidelines 2015 Writing Group
Dec 29, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lukas WinterThoralf Niendorf
Mar 2, 2016·Neurocritical Care·E GiulianiA Barbieri
Citations
Jul 18, 2019·Journal of Neurotrauma·John J WalshDaniel Coman
Jul 19, 2019·Neurocritical Care·Bernardo Lembo Conde de PaivaManoel Jacobsen Teixeira
Jul 18, 2020·Neurocritical Care·Raphael Einsfeld Simões FerreiraRicardo Silva Centeno
Jan 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Songyu ChenXiaofeng Jia