Abstract
Visual evaluation is the standard for amyloid positron emission tomography (PET) examination, though the result depends upon the physician's subjective review of the images. Therefore, it is expected that objective quantitative evaluation is useful for image interpretation. In this study, we examined the usefulness of the quantitative evaluation of amyloid PET using a PET-only quantification method in comparison with visual evaluation. In this study we retrospectively investigated a total of 166 individuals, including 58 cognitively normal controls, 62 individuals with mild cognitive impairment, and 46 individuals with early Alzheimer's disease. They underwent 11C-Pittsburgh compound-B (PiB) PET examination through the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). Amyloid accumulation in cerebral cortices was assessed using visual and quantitative methods. The quantitative evaluation was performed using the adaptive template method and empirically PiB-prone region of interest, and the standardized uptake value ratio (SUVR) in each area was obtained. Visual evaluation and SUVR were significantly correlated in the cerebral cortices (ρ = 0.85-0.87; p < 0.05). In visual evaluation, sensitivity, specificity, and acc...Continue Reading
References
Dec 3, 1999·British Journal of Clinical Pharmacology·B M McGleenonA P Passmore
Apr 18, 2002·Journal of the Neurological Sciences·Hiroyasu AkatsuKenji Kosaka
Feb 12, 2008·Brain : a Journal of Neurology·Clifford R JackRonald C Petersen
Mar 2, 2010·Lancet Neurology·Juha O RinneMichael Grundman
Aug 6, 2010·Annals of Neurology·Rik VandenbergheDavid J Brooks
Jan 20, 2011·JAMA : the Journal of the American Medical Association·Christopher M ClarkUNKNOWN AV45-A07 Study Group
Jul 4, 2012·Lancet Neurology·Christopher M ClarkUNKNOWN AV-45-A16 Study Group
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Nov 14, 2013·PloS One·Yi SuTammie L S Benzinger
Jan 16, 2014·PloS One·Luping ZhouUNKNOWN AIBL Research Group
Jan 18, 2014·European Journal of Nuclear Medicine and Molecular Imaging·L Saint-AubertJ Pariente
Aug 26, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lennart ThurfjellPaul Sherwin
Sep 27, 2014·Neurobiology of Aging·Pierrick BourgeatUNKNOWN AIBL Research Group
Jan 27, 2015·JAMA Neurology·Craig CurtisStephen Salloway
Apr 1, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Osama SabriUNKNOWN Florbetaben Phase 3 Study Group
Jul 14, 2016·Physics in Medicine and Biology·G AkamatsuM Senda
Dec 15, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Tomohiko YamaneUNKNOWN J-ADNI Study Group
May 14, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Takeshi IwatsuboUNKNOWN Alzheimer's Disease Neuroimaging Initiative