Feasibility study of a PET-only amyloid quantification method: a comparison with visual interpretation.

Annals of Nuclear Medicine
Natsumi ShimokawaMasayuki Sasaki

Abstract

Visual evaluation is the standard for amyloid positron emission tomography (PET) examination, though the result depends upon the physician's subjective review of the images. Therefore, it is expected that objective quantitative evaluation is useful for image interpretation. In this study, we examined the usefulness of the quantitative evaluation of amyloid PET using a PET-only quantification method in comparison with visual evaluation. In this study we retrospectively investigated a total of 166 individuals, including 58 cognitively normal controls, 62 individuals with mild cognitive impairment, and 46 individuals with early Alzheimer's disease. They underwent 11C-Pittsburgh compound-B (PiB) PET examination through the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). Amyloid accumulation in cerebral cortices was assessed using visual and quantitative methods. The quantitative evaluation was performed using the adaptive template method and empirically PiB-prone region of interest, and the standardized uptake value ratio (SUVR) in each area was obtained. Visual evaluation and SUVR were significantly correlated in the cerebral cortices (ρ = 0.85-0.87; p < 0.05). In visual evaluation, sensitivity, specificity, and acc...Continue Reading

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Citations

Sep 19, 2020·International Journal of Molecular Sciences·Mar PérezJesús Avila
Apr 7, 2021·Journal of Nuclear Medicine Technology·Yuma TsubakiUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative

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