Feasibility study of a system for combined light dosimetry and interstitial photodynamic treatment of massive tumors

Applied Optics
T JohanssonK Svanberg

Abstract

A system for the photodynamic laser treatment of massive tumors that employs multiple optical fibers to be inserted into the tumor mass is described. The light flux through the tumor can be assessed by use of the individual fibers both as transmitters and as receivers. With a computer model that describes the diffusive light propagation, optical dosimetry is under development. The system has been tested in an experimental animal tumor model in preparation for clinical work. Currently, delta-aminolevulinic acid is used as a sensitizer, activated by 635-nm radiation from a 2.0-W compact diode laser system. With the availability of future, highly selective drugs absorbing approximately 750 nm, larger tumor volumes should be treatable, and surrounding, sensitive normal tissue should be spared.

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Citations

Aug 31, 2010·Journal of Biomedical Optics·Katarina SvanbergSune Svanberg
Nov 9, 2010·Journal of Biomedical Optics·Johannes SwartlingStefan Andersson-Engels
Jan 18, 2005·IEEE Transactions on Bio-medical Engineering·Anders KarlssonStefan Andersson-Engels
Dec 10, 2002·Journal of Clinical Laser Medicine & Surgery
Feb 18, 2016·Journal of Biomedical Optics·Johannes SwartlingAnne-Sofie Lagerstedt
Jul 11, 2006·Journal of Biomedical Optics·Ann JohanssonStefan Andersson-Engels
Jul 12, 2005·Applied Optics·Marcelo Soto ThompsonKatarina Svanberg
Dec 1, 2004·Journal of Biomedical Optics·Subhadra SrinivasanKeith D Paulsen
Oct 23, 2004·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Jiangping HeStefan Andersson-Engels
Apr 9, 2005·Applied Optics·Johannes SwartlingStefan Andersson-Engels
May 13, 2004·Photochemistry and Photobiology·Stuart K BislandLothar Lilge
Mar 11, 2016·Physics in Medicine and Biology·Brian W PogueTayyaba Hasan

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