Feasibility Study of Catheter-Based Interventions for Anisotropic Expanded Polytetrafluoroethylene Cardiovascular Conduits in a Growing Lamb Model.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Anthony AzakieR Bianco

Abstract

Cardiovascular repair in children often requires implant of conduits which do not have growth potential and will require reoperation. In the current study we sought to determine the feasibility of catheter-based interventions of anisotropic conduits inserted as interposition grafts in the main pulmonary artery (MPA) of growing lambs. Lambs underwent interpositional implant of either an anisotropic expanded polytetrafluoroethylene (ePTFE) (Test) conduit or conventional PTFE (Control) conduit. In the postoperative period, lambs were anesthetized and underwent catheter-based interventions consisting of hemodynamic and angiographic data collection, balloon dilation and/or stenting of the conduit at 3, 6 or 9 month postoperative time point. At 3 months, control lambs showed significant increases in right ventricular pressures and trans-conduit gradients in comparison to test lambs. Test conduit diameters were significantly larger compared to controls due to spontaneous radial expansion of the anisotropic conduit. Balloon dilation of test conduits at 3 and 6 months showed a reduction in RV pressure and statistically significant improvement in the RV outflow tract gradient as well as significant increase in graft diameter, compared to...Continue Reading

References

Aug 1, 1976·The Surgical Clinics of North America·J A Schilling
Jan 1, 1995·The Journal of Surgical Research·D A BullC W Putnam
Jun 1, 1997·The Surgical Clinics of North America·M B Witte, A Barbul
Jun 24, 1998·Pediatric Cardiology·J Stark
Apr 28, 2006·Pediatric Research·Younes BoudjemlinePhilipp Bonhoeffer
Jul 28, 2009·The Annals of Thoracic Surgery·Justin P V ZachariahDoff B McElhinney
Sep 25, 2010·Journal of the American College of Cardiology·Paul KhairyAriane J Marelli
Nov 15, 2011·Journal of the American College of Cardiology·Denise van der LindeJolien W Roos-Hesselink
Aug 3, 2013·Rambam Maimonides Medical Journal·David Kalfa, Emile Bacha
Aug 27, 2013·The Annals of Thoracic Surgery·Jeffrey A PoynterUNKNOWN Congenital Heart Surgeons' Society
Dec 15, 2015·The Annals of Thoracic Surgery·Erin G RobertsSitaram M Emani
Apr 14, 2016·Annals of Biomedical Engineering·Jay ReimerRobert Tranquillo
Apr 17, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ravil SharifulinAlexander Karaskov
Feb 23, 2020·Science Translational Medicine·Sophie C HofferberthPedro J Del Nido

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Related Papers

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Anthony AzakieR Bianco
World Journal for Pediatric & Congenital Heart Surgery
Laura M SeeseVictor O Morell
The Journal of Thoracic and Cardiovascular Surgery
J StarkM de Leval
© 2021 Meta ULC. All rights reserved