Feasibility study of chitosan as intravitreous tamponade material.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Hong YangXiaonong Zhang

Abstract

Chitosan can inhibit fibroblastic proliferation by suppressing fibroblast cells, and has the similar physiological characteristics as normal vitreous body, so it might have the potential to become vitreous filling material and might possibly inhibit proliferative vitreous retinopathy. To investigate the possibility of chitosan as vitreous filling material, this study was designed to investigate retina, ciliary body, lens and cornea morphology changes, intraocular pressure and intraocular inflammatory factors fluctuating after chitosan intravitreous tamponade. Fifteen healthy chinchilla rabbits were chosen; three of them were a blank (negative) control group without any surgical procedure. The remaining 12 rabbits received vitrectomy on both eyes; all the right eyes (experimental group) were given 1.2-1.8 ml (average 1.5 ml) of chitosan intravitreously, while sodium hyaluronate were given in the left eyes (control group). All eyes underwent slit-lamp biomicroscope and indirect ophthalmoscope examination and intraocular pressure measurement pre- and post-op. The concentration of IL-6, IL-8 (radioimmunoassay), NO (nitrate reductase method) in aqueous humor and vitreous body were tested at day 15 and day 30 post-op. At day 30 post-...Continue Reading

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Citations

Apr 1, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sven CrafoordFredrik Ghosh
Apr 30, 2013·Acta Biomaterialia·Sarah WassmerCatherine Tsilfidis
May 24, 2011·Survey of Ophthalmology·Teri T KleinbergShalesh Kaushal
Sep 15, 2015·Biomacromolecules·Xinyi SuXian Jun Loh
Oct 10, 2012·Carbohydrate Polymers·Natália R PiresJudith P A Feitosa
Apr 11, 2014·BioMed Research International·Girish K SrivastavaJ Carlos Pastor
May 31, 2014·BioMed Research International·Simone DonatiClaudio Azzolini
Dec 5, 2009·Advanced Drug Delivery Reviews·Maria de la FuenteMaria Jose Alonso
Dec 16, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Indu YadavNarayan Chandra Mishra
Dec 29, 2020·Frontiers in Bioengineering and Biotechnology·Haozhe YuYun Feng
Jan 2, 2021·Translational Vision Science & Technology·André SchulzPeter Szurman

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