Feasibility study of concurrent weekly cisplatin and whole abdominopelvic irradiation followed by doxorubicin/cisplatin chemotherapy for advanced stage endometrial carcinoma: a Gynecologic Oncology Group trial

Gynecologic Oncology
John T SoperD L Clarke-Pearson

Abstract

A prospective Phase I study to determine toxicity of concurrent weekly intravenous cisplatin/whole abdominopelvic radiation therapy followed by four cycles of intravenous doxorubicin/cisplatin chemotherapy. Ten patients with advanced endometrial cancer confined to the abdominal cavity and/or paraaortic lymph nodes with small residual disease were treated postoperatively with 3000 cGy whole abdominopelvic irradiation combined with 1500 cGy boost to the pelvis or pelvic and aortic fields. Cisplatin 15 mg/m(2) was given every week during irradiation. After completing radiotherapy, patients were to receive doxorubicin 50 mg/m(2) and cisplatin 50 mg/m(2) every 3 weeks for four cycles. Graduated dose reduction and acceleration of the doxorubicin dose were specified depending upon hematologic toxicity. Toxicities were monitored with weekly laboratory studies during treatment and frequent examinations. Five patients with Stage IIIC (paraaortic node involvement) and five with Stage IVB disease were treated on this study. Acute toxicity during chemoirradiation included one patient with grade 4 neutropenia and one patient with persistent grade 1 thrombocytopenia. Seven patients received chemotherapy after completing radiation therapy, two...Continue Reading

References

Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A MartinezG Malkasian
Aug 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C TropéE Cavallin-Ståhl
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Citations

Jul 9, 2010·Obstetrics and Gynecology International·Ying Zhang, Jian Wang
Jul 28, 2010·The Oncologist·J Alejandro Rauh-Hain, Marcela G Del Carmen
Sep 10, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Honglei ZhaoLiancheng Lei
Aug 10, 2006·Best Practice & Research. Clinical Obstetrics & Gynaecology·Sean Kehoe
Apr 26, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Qiang WenZhengYan Yang
May 28, 2009·Journal of Gynecologic Oncology·Howard D Homesley
Aug 12, 2005·Current Opinion in Oncology·Katharina Kieser, Amit M Oza

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