Feasibility study of early blood pressure management in extremely preterm infants.

The Journal of Pediatrics
Beau BattonEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Abstract

To assess the feasibility of a randomized placebo controlled trial (RCT) of blood pressure (BP) management for extremely preterm infants. This was a prospective pilot RCT of infants 23-0/7 to 26-6/7 weeks gestation who had protocol-defined low BP in the first 24 postnatal hours. Enrolled infants were administered a study infusion (dopamine or placebo) and a study syringe medication (hydrocortisone or placebo). Of the 366 infants screened, 119 (33%) had low BP, 58 (16%) met all entry criteria, and 10 (3%) were enrolled. A total of 161 infants (44%) were ineligible because they received early indomethacin. Only 17% of eligible infants were enrolled. Problems with consent included insufficient time, parent unavailability, and physician unwillingness to enroll critically ill infants. Two infants were withdrawn from the study because of the potential risk of intestinal perforation with simultaneous administration of hydrocortisone and indomethacin. This pilot RCT was not feasible because of low eligibility and consent rates. An RCT of BP management for extremely preterm infants may require a waiver of consent for research in emergency care. The frequent use of early indomethacin and the associated risk of intestinal perforation when...Continue Reading

References

Nov 1, 1993·Pediatric Research·F De ZegherJ D Veldhuis
Oct 19, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·J LeeK W Tan
Mar 29, 2000·Early Human Development·K LundstrømG Greisen
Sep 6, 2001·Journal of Perinatology : Official Journal of the California Perinatal Association·I Al-AweelD K Richardson
Jun 26, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Leandro CorderoLarry A Sachs
Dec 4, 2003·Early Human Development·S E MartensUNKNOWN Leiden Follow-Up Project on Prematurity, The Netherlands
Mar 3, 2006·Pediatrics·Neil N FinerUNKNOWN California Perinatal Quality Care Collaborative Executive Committee
Aug 25, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·E M Dempsey, K J Barrington
Feb 17, 2007·American Journal of Perinatology·Beau BattonThomas Riggs
Mar 3, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Luca FilippiCristina Santoro
Jul 27, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·E M Dempsey, K J Barrington
Nov 26, 2008·The Journal of Pediatrics·Beau BattonMichele Walsh
Jan 29, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·E M DempseyK J Barrington
Jul 1, 2010·Pediatrics·Wade D RichUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Dec 9, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·J Wells LoganUNKNOWN ELGAN Study Investigators

❮ Previous
Next ❯

Citations

Apr 27, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·M H LightburnJ R Kaiser
Jun 27, 2013·Pediatric Research·Alexandra SchwepckeOrsolya Genzel-Boroviczény
Aug 9, 2013·European Journal of Pediatrics·E M Dempsey, K Connolly
Oct 21, 2015·Pediatrics and Neonatology·Tai-Wei WuIstvan Seri
Jul 1, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Eugene Michael Dempsey
Feb 28, 2015·The Journal of Pediatrics·Nestor E VainGonzalo L Mariani
Apr 10, 2012·The Journal of Pediatrics·Nestor Eduardo Vain, Keith J Barrington
May 9, 2016·The Journal of Pediatrics·Kristi L Watterberg
Nov 15, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Beau BattonUNKNOWN Eunice Kennedy Shriver National Institute of Child Health & Human Development Neonatal Research Network
May 26, 2017·Neonatology·Eugene M Dempsey
Jul 28, 2018·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sujith Stanley PereiraStephen Terence Kempley
Oct 25, 2017·The Cochrane Database of Systematic Reviews·Lex W DoyleHenry L Halliday
Oct 25, 2017·The Cochrane Database of Systematic Reviews·Lex W DoyleHenry L Halliday
Apr 24, 2018·Frontiers in Pediatrics·Aisling A GarveyEugene M Dempsey
Feb 26, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Eugene M DempseyUNKNOWN HIP consortium
Mar 25, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Laura E MillerRachel G Greenberg
Mar 12, 2019·American Journal of Obstetrics and Gynecology·Haruo UsudaMatthew W Kemp
May 3, 2021·Pediatric Research·Gorm Greisen
Nov 11, 2021·The Cochrane Database of Systematic Reviews·Lex W DoyleHenry L Halliday

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Archives of Disease in Childhood. Fetal and Neonatal Edition
E M DempseyKeith J Barrington
Clinics in Perinatology
E M Dempsey, Keith J Barrington
The New England Journal of Medicine
Barbara SchmidtTrial of Indomethacin Prophylaxis in Preterms Investigators
Seminars in Fetal & Neonatal Medicine
F W J te BraakeJ B van Goudoever
© 2022 Meta ULC. All rights reserved