Feasibility study on the retention of superporous hydrogel composite polymer in the intestinal tract of man using scintigraphy

Journal of Controlled Release : Official Journal of the Controlled Release Society
F A DorkooshH E Junginger

Abstract

In recent years, many complex oral drug delivery systems have been developed using various polymers in order to achieve better drug targeting and drug absorption in the intestinal tract. Superporous hydrogel (SPH) and SPH composite (SPHC)-based drug delivery systems were also developed for the targeted delivery of peptide drugs into the intestinal tract. In the present study, the retention time of SPHC polymer is studied in man using the scintigraphy technique. To that purpose, SPHC polymers were radiolabelled with Tc-99m and administered orally in an enteric-coated gelatin capsule. The location of the radiolabelled polymer was monitored in five healthy volunteers while the subjects were sitting in front of a large field of view gamma camera. The results showed that enteric-coated gelatin capsules remained in the stomach for 75 to 150 min after oral administration to fasted volunteers and that the SPHC polymers thereafter attached to the upper part of the small intestine for at least 45 to 60 min due to their mechanical fixation properties. No discomfort was observed in any of the volunteers after oral administration of these polymers, which indicates that they are safe to be applied for oral drug delivery systems in man.

References

Apr 11, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·F A DorkooshH E Junginger
Mar 7, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Farid A DorkooshHans E Junginger
Jun 28, 2002·International Journal of Pharmaceutics·Farid A DorkooshHans E Junginger
Sep 6, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Sunita Rao, Vikram Lele
Nov 14, 2002·International Journal of Pharmaceutics·F A DorkooshH E Junginger

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Citations

Jan 7, 2004·International Journal of Pharmaceutics·Assadang PolnokHans E Junginger
Apr 11, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·F A DorkooshH E Junginger
Apr 1, 2010·Journal of Pharmacy & Bioallied Sciences·Hitesh Chavda, Chhaganbhai Patel
Feb 2, 2013·International Journal of Pharmaceutical Investigation·Hitesh V ChavdaChhagan N Patel
Dec 12, 2012·Advanced Drug Delivery Reviews·Taslim A Al-HilalYoungro Byun
Dec 8, 2011·Expert Opinion on Drug Delivery·David J MastropietroKinam Park
Dec 29, 2005·Journal of Pharmaceutical Sciences·Takahiro GotoNicholas A Peppas
Jan 17, 2016·Macromolecular Bioscience·Kambiz FarbodSander C G Leeuwenburgh
Sep 21, 2007·Advanced Drug Delivery Reviews·El-Sayed KhafagyKozo Takayama
Oct 13, 2006·International Journal of Pharmaceutics·Iman S Ahmed, James W Ayres
Nov 29, 2005·International Journal of Pharmaceutics·Mia SäkkinenMartti Marvola
Jul 5, 2005·Drug Discovery Today·Sarah L Tao, Tejal A Desai
Jun 21, 2016·Advanced Drug Delivery Reviews·Sam MaherDavid J Brayden
Mar 10, 2017·Drug Development and Industrial Pharmacy·Jéssica Bassi da SilvaMarcos Luciano Bruschi
Mar 3, 2007·The Journal of Pharmacy and Pharmacology·Hossein OmidianJose G Rocca
Aug 21, 2019·AAPS PharmSciTech·Gábor VasváriFerenc Fenyvesi
May 31, 2021·Advanced Drug Delivery Reviews·Zhi LuoJean-Christophe Leroux
Aug 22, 2021·Advanced Drug Delivery Reviews·Sam Maher, David J Brayden

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