PMID: 9443340Jan 27, 1998Paper

Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides

Proteins
G SchneiderG von Heijne

Abstract

Cleavage sites in nuclear-encoded mitochondrial protein targeting peptides (mTPs) from mammals, yeast, and plants have been analysed for characteristic physicochemical features using statistical methods, perceptrons, multilayer neural networks, and self-organizing feature maps. Three different sequence motifs were found, revealing loosely defined arginine motifs with Arg in positions -10, -3, and -2. A self-organizing feature map was able to cluster these three types of endopeptidase target sites but did not identify any species-specific characteristics in mTPs. Neural networks were used to define local sequence features around precursor cleavage sites.

Citations

May 25, 1999·Protein Science : a Publication of the Protein Society·O EmanuelssonG von Heijne
Apr 23, 2002·Protein Science : a Publication of the Protein Society·Abhijit MukhopadhyayHenry Weiner
Sep 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yong WangJames C Wang
Mar 7, 2003·Applied and Environmental Microbiology·Olga MartinAlan T Bakalinsky
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·C LaloiY Meyer
Nov 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guoqiang XuSamie R Jaffrey
Nov 3, 2010·Eukaryotic Cell·Maria José BarberàAndrew J Roger
Nov 17, 2010·BMC Plant Biology·Chris CarrieJames Whelan
Aug 26, 1999·The Journal of Eukaryotic Microbiology·G I McFadden
Feb 15, 2008·Plant Physiology and Biochemistry : PPB·Andrew J PerryPaul R Gooley
May 24, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yen-Ling ChenZee-Fen Chang
Nov 30, 2007·Molecular Microbiology·Erin E GillAndrew J Roger
May 31, 2012·Human Mutation·Chou Hung SimHeung-Chin Cheng
Apr 13, 2012·Biochimica Et Biophysica Acta·Pedro Filipe Teixeira, Elzbieta Glaser
Dec 15, 2010·Molecular and Cellular Endocrinology·Andrew MidzakVassilios Papadopoulos
Aug 23, 2002·Biochimica Et Biophysica Acta·Oleksandr GakhGrazia Isaya

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