Feature Genes Selection Using Fuzzy Rough Uncertainty Metric for Tumor Diagnosis

Computational and Mathematical Methods in Medicine
Jiucheng XuTianli Zhang

Abstract

To select more effective feature genes, many existing algorithms focus on the selection and study of evaluation methods for feature genes, ignoring the accurate mapping of original information in data processing. Therefore, for solving this problem, a new model is proposed in this paper: rough uncertainty metric model. First, the fuzzy neighborhood granule of the sample is constructed by combining the fuzzy similarity relation with the neighborhood radius in the rough set, and the rough decision is defined by using the fuzzy similarity relation and the decision equivalence class. Then, the fuzzy neighborhood granule and the rough decision are introduced into the conditional entropy, and the rough uncertainty metric model is proposed; in the meantime, the definition of measuring the significance of feature genes and the proof of some related theorems are given. To make this model tolerate noises in data, this paper introduces a variable precision model and discusses the selection of parameters. Finally, based on the rough uncertainty metric model, we design a feature genes selection algorithm and compare it with some existing similar algorithms. The experimental results show that the proposed algorithm can select the smaller fea...Continue Reading

References

Aug 1, 2013·IEEE Transactions on Cybernetics·Jianhua DaiQing Xu
Apr 19, 2018·Computational and Mathematical Methods in Medicine·Jiucheng XuFangzhou Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
chip

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.