Feature selection for the automated detection of metaphase chromosomes: performance comparison using a receiver operating characteristic method

Analytical Cellular Pathology (Amsterdam)
Yuchen QiuHong Liu

Abstract

The purpose of this study is to identify a set of features for optimizing the performance of metaphase chromosome detection under high throughput scanning microscopy. In the development of computer-aided detection (CAD) scheme, feature selection is critically important, as it directly determines the accuracy of the scheme. Although many features have been examined previously, selecting optimal features is often application oriented. In this experiment, 200 bone marrow cells were first acquired by a high throughput scanning microscope. Then 9 different features were applied individually to group captured images into the clinically analyzable and unanalyzable classes. The performance of these different methods was assessed by a receiving operating characteristic (ROC) method. The results show that using the number of labeled regions on each acquired image is suitable for the first on-line CAD scheme. For the second off-line CAD scheme, it would be suggested to combine four feature extraction methods including the number of labeled regions, average regions area, average region pixel value, and the standard deviation of either region distance or circularity. This study demonstrates an effective method of feature selection and compa...Continue Reading

References

Mar 1, 1992·Journal of Radiation Research·K R Castleman
Feb 10, 1998·Medical Decision Making : an International Journal of the Society for Medical Decision Making·C E MetzC A Roe
Sep 15, 1998·IEEE Transactions on Medical Imaging·R J StanleyC W Caldwell
Feb 5, 2000·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·J M Cho
Jul 24, 2001·Medical & Biological Engineering & Computing·F Arámbula CosíoG Corkidi
Apr 6, 2004·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seong Ho ParkChan-Hee Jo
Apr 15, 2004·Artificial Intelligence in Medicine·Boaz Lerner
Apr 29, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Béla KajtárLászló Pajor
Jul 27, 2006·Technology in Cancer Research & Treatment·Xingwei WangBin Zheng
Aug 8, 2007·Journal of Biomedical Informatics·Xingwei WangBin Zheng
Dec 18, 2007·Computer Methods and Programs in Biomedicine·Xingwei WangHong Liu
Jul 1, 2008·Journal of Biomedical Informatics·Xingwei WangHong Liu
Feb 6, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Enrico GrisanAlfredo Ruggeri
Jan 21, 2012·Computer Methods and Programs in Biomedicine·Enea PolettiEnrico Grisan
Sep 1, 2012·Analytical Cellular Pathology (Amsterdam)·Xingwei WangBin Zheng

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Citations

Dec 18, 2015·Medical & Biological Engineering & Computing·Tanvi Arora, Renu Dhir

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Methods Mentioned

BETA
feature extraction

Software Mentioned

ROCKIT

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