Features and severity of occupational asthma upon diagnosis: an Italian multicentric case review

Allergy
G MoscatoA Siracusa

Abstract

The severity of occupational asthma (OA) at the time of diagnosis is not known. In this study we aimed to evaluate some features of the disease at the time of diagnosis, particularly looking at severity and treatment before diagnosis. Medical records of subjects (n = 197) who had received a diagnosis of OA in six specialized centres of Northern and Central Italy in the period 1992-97 were reviewed. The severity of the disease at the time of diagnosis was determined on the basis of symptoms, peak expiratory flow (PEF, percentage predicted), forced expiratory volume in one second (FEV1, percentage predicted), and PEF variability, following the criteria of the National Institutes of Health and World Health Organizaton (NIH/WHO) guidelines on asthma. Medications used in the month before diagnosis were recorded. The most common etiological agents were isocyanates (41.6%), flours (19.8%), woods (9.7%) and natural rubber latex (7.6%). The level of asthma severity (AS) was mild intermittent in 23.9% patients, mild persistent in 28.9%, moderate in 41.6%, and severe in 5.6%. Asthma severity was positively associated with current or previous smoking (P < 0.05), and was not related to atopy and current exposure. A relationship with bronchi...Continue Reading

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Citations

Jan 20, 2006·International Archives of Occupational and Environmental Health·L Barbinova, X Baur
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Nov 28, 2012·International Journal of Occupational Medicine and Environmental Health·Dominika Świerczyńska-MachuraCezary Pałczyński
May 3, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SiracusaG Moscato
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Oct 16, 2018·Current Opinion in Pulmonary Medicine·Santiago Quirce, Joaquín Sastre
Jun 30, 2018·Allergy·Olivier VandenplasUNKNOWN European network for the PHenotyping of OCcupational ASthma (E-PHOCAS) investigators
Apr 22, 2019·Occupational and Environmental Medicine·Mahsa TaghiakbariEva Suarthana
Jan 15, 2013·The Annals of Occupational Hygiene·Natascia MagagnottiDaniela Volpi

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