Abstract
The measurements used to define pulmonary hypertension (PH) etiology, pulmonary arterial wedge pressure (PAWP), and left ventricular end-diastolic pressure (LVEDP) vary in clinical practice. We aimed to identify clinical features associated with measurement discrepancy between PAWP and LVEDP in patients with PH. We extracted clinical data and invasive hemodynamics from consecutive patients undergoing concurrent right and left heart catheterization at Vanderbilt University between 1998 and 2014. The primary outcome was discordance between PAWP and LVEDP in patients with PH in a logistic regression model. We identified 2,270 study subjects (median age, 63 years; 53% men). The mean difference between PAWP and LVEDP was -1.6 mm Hg (interquartile range, -15 to 12 mm Hg). The two measurements were moderately correlated by linear regression (R = 0.6, P < .001). Results were similar when restricted to patients with PH. Among patients with PH (n = 1,331), older age (OR, 1.77; 95% CI, 1.23-2.45) was associated with PAWP underestimation in multivariate models, whereas atrial fibrillation (OR, 1.75; 95% CI, 1.08-2.84), a history of rheumatic valve disease (OR, 2.2; 95% CI, 1.36-3.52), and larger left atrial diameter (OR, 1.70; 95% CI, 1.24...Continue Reading
References
Dec 1, 1974·Chest·D L RiceD E Jenkins
Jun 15, 2004·Journal of the American College of Cardiology·Gerald SimonneauAlfred Fishman
May 27, 2008·Clinical Pharmacology and Therapeutics·D M RodenD R Masys
Mar 4, 2009·Chest·Scott D Halpern, Darren B Taichman
Nov 17, 2009·Journal of Applied Physiology·Negin BehazinStephen H Loring
May 7, 2010·Clinical and Translational Science·Jill PulleyDaniel R Masys
Jun 8, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Omri GottesmanUNKNOWN eMERGE Network
Nov 26, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rudolf K F OliveiraJaquelina S Ota-Arakaki
Dec 4, 2013·Circulation. Heart Failure·Ivan M RobbinsJohn H Newman
Dec 21, 2013·Journal of the American College of Cardiology·Jean-Luc VachiéryWerner Seeger
Dec 21, 2013·Journal of the American College of Cardiology·Marius M HoeperDavid B Badesch
Feb 1, 2014·Chest·Meredith E PughAnna R Hemnes
Feb 6, 2014·PloS One·Abbas BitarTim Lahm
Jun 14, 2014·The European Respiratory Journal·Barbara L LeVargeRichard N Channick
Sep 30, 2016·Pulmonary Circulation·Tufik R AssadAnna R Hemnes
Dec 10, 2016·Journal of the American College of Cardiology·Tufik R AssadEvan L Brittain
Sep 16, 2017·Circulation. Heart Failure·Stephen P WrightSusanna Mak
Sep 16, 2017·Circulation. Heart Failure·Brian A Houston, Ryan J Tedford
Sep 28, 2017·European Journal of Heart Failure·Michael G DickinsonElke S Hoendermis
Sep 28, 2017·European Journal of Heart Failure·Brian A Houston, Ryan J Tedford
Oct 13, 2017·European Journal of Heart Failure·David M KayeSanjiv J Shah
Oct 17, 2017·JACC. Heart Failure·Julia MascherbauerDiana Bonderman
Oct 27, 2017·JAMA Cardiology·Tufik R AssadEvan L Brittain
Feb 9, 2018·Current Heart Failure Reports·Bhavadharini RamuRyan J Tedford
Mar 29, 2018·JAMA Cardiology·Yogesh N V ReddyRick A Nishimura
Citations
Aug 27, 2019·Circulation·Robert Naeije, Kelly Chin
Mar 14, 2019·Current Opinion in Critical Care·Anthony S McLean
May 8, 2020·Cardiac Failure Review·Sriram D RaoJeremy A Mazurek
Dec 21, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Olivier Sitbon, Luke Howard
Sep 3, 2019·Journal of the American Heart Association·Vineet AgrawalEvan L Brittain
Jun 25, 2020·Pulmonary Circulation·Ralf EwertDirk Habedank
Jan 7, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·David F MeoliKen Monahan
Aug 18, 2020·Chest·Michele D'AltoRobert Naeije
Jan 19, 2020·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andriy O SamokhinBradley A Maron
Nov 27, 2020·Pulmonary Circulation·Shelsey W JohnsonRichard Channick
Feb 3, 2020·Journal of Cardiac Failure·Emmanuelle BerthelotPatrick Assayag
Jun 17, 2021·Annales de cardiologie et d'angéiologie·S ArquesE Roux
Jun 17, 2021·Annales de cardiologie et d'angéiologie·S ArquesE Roux
Jun 17, 2021·Annales de cardiologie et d'angéiologie·S Arques