Features of Japanese patients with myelodysplastic syndrome in an aging population of Sado Island.

International Journal of Hematology
Kumiko YagisawaYoshifusa Aizawa

Abstract

Myelodysplastic syndrome (MDS) is relatively common in the elderly, and aging of populations is progressing in developed nations, notably so in Japan. The major age group in Japan and Sado Island are distributed between 30 and 60 and between 50 and 80, respectively. The aim of this study was to analyze the features of MDS in the population of Sado Island to anticipate the characteristics of the disease in the near future. One-hundred and fifty-three patients (71 male, 82 female, 19-94 years old, median 73 years old) with de novo MDS between 1985 and 2005 were retrospectively evaluated. All patients were reclassified according to WHO-2001 criteria. The predictive power of the international prognostic scoring system and the WHO classification-based prognostic scoring system were evaluated. The major causes of death were leukemic transformation (38%) in refractory anemia with an excess of blasts and infection (48%) for total MDS. Age was another independent prognostic factor. Elderly patients exhibited a significantly poorer prognosis mainly due to infections such as pneumonia. Although novel remedies for MDS and hyperferremia have recently been developed, prevention of infection remains important in MDS, particularly for older pa...Continue Reading

References

Oct 1, 1992·British Journal of Haematology·C AulW Schneider
Mar 1, 1991·The American Journal of Medicine·C PomeroyG A Filice
Jun 1, 1982·British Journal of Haematology·J M BennettC Sultan
Mar 1, 1995·European Journal of Haematology·A RådlundL Engquist
Aug 1, 1994·British Journal of Haematology·P J WilliamsonD G Oscier
Jan 25, 2003·British Journal of Haematology·David BowenUNKNOWN UK MDS Guidelines Group
Oct 6, 2006·The New England Journal of Medicine·Alan ListUNKNOWN Myelodysplastic Syndrome-003 Study Investigators
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luca MalcovatiMario Cazzola
Aug 1, 2008·Leukemia·T TasakaUNKNOWN Japanese Cooperative Study Group for Intractable Bone Marrow Diseases
Dec 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matteo Giovanni Della PortaMario Cazzola
Jul 17, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T NösslingerM Pfeilstöcker
Feb 18, 2010·Cancer·Farshid DayyaniGuillermo Garcia-Manero
Jul 3, 2010·Leukemia Research·Massimo BrecciaGiuliana Alimena
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masako IwanagaMasao Tomonaga

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