Features of lymphatic dysfunction in compressed skin tissues - Implications in pressure ulcer aetiology

Journal of Tissue Viability
Robert J GrayDan L Bader

Abstract

Impaired lymph formation and clearance has previously been proposed as a contributory factor in the development of pressure ulcers. The present study has been designed to trial fluorescence lymphangiography for establishing how lymphatic function is altered under a clinically relevant form of mechanical loading. Lymph formation and clearance was traced in both forearms by an intradermal injection of indocyanine green (ICG) (50 μl, 0.05%w/v), imaged using a commercial near-infrared fluorescence imaging unit (Fluobeam(®) 800). External uniaxial loading equivalent to a pressure of 60 mmHg was applied for 45 min in one arm using a custom-built indenter. Loading was associated with a decreased frequency of normal directional drainage (DD) of ICG within delineated vessels, both immediately after loading and 45 min thereafter. Loading was also associated with non-directional drainage (NDD) of ICG within the interstitium. Signal intensity within NDD was often greatest at areas of stress concentration, producing a 'halo pattern', corresponding to the rounded edges of the indenter. These results suggest that loading skin with a clinically relevant magnitude of pressure alters both lymph formation and clearance. Further work to quantify i...Continue Reading

References

Feb 1, 1987·Journal of Biomechanical Engineering·G E Miller, J L Seale
Jan 1, 1981·Journal of Biomechanics·N P Reddy, G V Cochran
Dec 31, 2004·Lymphatic Research and Biology·Waldemar L Olszewski
Jul 13, 2006·PLoS Medicine·Raymond TabibiazarStanley G Rockson
Nov 22, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Vivian K WongGlenna A Dowling
Jun 22, 2010·International Wound Journal·Joyce M BlackMaureen R Kelpe
Jul 29, 2010·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Gina BergEmily Hennes
May 12, 2012·International Journal of Biomedical Imaging·Jarmo T AlanderPetri Välisuo
Aug 14, 2012·Journal of Wound Care·C DealeyA Walker
Jun 25, 2013·Journal of the Mechanical Behavior of Biomedical Materials·C Y Chai, D L Bader
Jan 17, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tyler S NelsonJ Brandon Dixon

❮ Previous
Next ❯

Citations

Jun 2, 2016·Medical Engineering & Physics·R J GrayD L Bader
Apr 14, 2018·Biomedical Engineering Online·Dan L Bader, Peter R Worsley
Jul 1, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peter R WorsleyDan L Bader
Jan 14, 2021·Journal of Wound Care·Pinar AvsarDeclan Patton
Dec 31, 2020·International Journal of Molecular Sciences·Stephen M NiemiecCarlos Zgheib
Aug 13, 2021·International Wound Journal·Amit GefenJan Kottner

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Immunological Methods
S Kwon, E M Sevick-Muraca
Nihon rinsho. Japanese journal of clinical medicine
A MiyazakiN Sato
Fukuoka igaku zasshi = Hukuoka acta medica
S HIROSE
© 2022 Meta ULC. All rights reserved