PMID: 1793853Jul 1, 1991

Features of oxidative phosphorylation in brain mitochondria of rats with different sensitivity to oxygen insufficiency

Biulleten' eksperimental'noĭ biologii i meditsiny
L D Luk'ianovaG N Chernobaeva


Oxidative phosphorylation parameters have been investigated in the isolated brain mitochondria of rats preliminary divided into non-resistant (NR) and high-resistant (HR) animals by their sensitivity to hypobaric hypoxia. During the NAD-dependent substrates oxidation it was shown that the identical effectiveness of the respiratory chain function in both groups of animals was reached at more tension of the oxidative processes. It has been established that at the identical effectiveness of the succinate oxidation by the brain mitochondria in both groups of animals compensatory potentialities of the succinate-oxidase pathway of oxidation is higher in the brain of the NR to hypoxia animals. It has been shown the regulated influence of the NAD-dependent pathway of oxidation activity on the succinate-oxidase site of respiratory chain. This influence is more expressed in the brain mitochondria of the NR animals that in the HR animals.

Related Concepts

Biochemical Pathway
Oxidation Activity [MoA]
Succinate oxidase

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