Features of peripheral CD8+ CD57+ lymphocytes in patients with autoimmune hemolytic anemia

Autoimmunity
Maria Celeste FatoneSabino Russi

Abstract

Autoimmune hemolytic anemia (AIHA) is an acquired condition characterized by the presence of autoantibodies recognizing erythrocyte-related antigens. Several components of the immune system are involved in disease pathogenesis. Among them, as for other autoimmune disorders, a role for specific CD8+CD57+ regulatory cells subset could be hypothesized. We evaluated this lymphocyte subset by flow cytometry in 18 AIHA patients randomly selected in a retrospective population of 29 cases. Secondary forms were observed in 65.5% of cases, whereas frequencies of warm, cold, mixed, and atypical forms were similar. Cold agglutinins and cryoglobulins tested positive in 44.8% and 10.3% of cases, respectively. These patients exhibited a higher frequency of peripheral vascular symptoms (odds ratio = 8.2, p = .04) and complement consumption (odds ratio = 7.2, p = .02). Frequency of CD8+CD57+ cells resulted significantly higher in AIHA patients than in control group (17.0 ± 15.8% vs 8.2 ± 5.0%, p = .04). Regardless of therapeutic schedule, patients with partial or no response to therapy (8/18) showed higher frequencies of CD8+CD57+ cells as compared with controls (23.6 ± 21.3% vs 8.9 ± 4.9%, p = .01), whereas 10/18 complete responders (CR) showe...Continue Reading

References

Feb 1, 1997·Arthritis and Rheumatism·E C WangL K Borysiewicz
Mar 21, 1998·British Journal of Haematology·M A FrassanitoF Dammacco
Oct 26, 1999·European Journal of Haematology·E UlvestadF V Shammas
Jul 17, 2001·European Journal of Clinical Investigation·F DammaccoV Racanelli
Mar 7, 2002·Arthritis Research·Michael SchirmerAlbrecht Falkenbach
Mar 29, 2002·American Journal of Hematology·Bradley C Gehrs, Richard C Friedberg
Dec 3, 2005·Leukemia & Lymphoma·Claudia SchöllkopfHenrik Birgens
May 4, 2007·The British Journal of Ophthalmology·Miguel Pedroza-SeresMaria Carmen Jimenez-Martinez
Sep 28, 2007·Cardiovascular & Hematological Disorders Drug Targets·Sigbjørn BerentsenGeir E Tjønnfjord
Jul 16, 2008·Lupus·A TulunayE Eksioglu-Demiralp
Aug 16, 2008·Journal of Clinical Immunology·Zhiping SunXueguang Zhang
Sep 25, 2008·Human Immunology·Masakatsu SuzukiCornelia M Weyand
Mar 6, 2009·The Journal of Investigative Dermatology·Anna BalatoAnthony A Gaspari
Jun 23, 2009·Trends in Immunology·Nan-Ping WengJorg Goronzy
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andreas E R FasthVivianne Malmström
Nov 3, 2009·Journal of Leukocyte Biology·Daniele FocosiMario Petrini
Jan 14, 2011·Haematologica·Nathalie AladjidiUNKNOWN Centre de Référence National des Cytopénies Auto-immunes de l'Enfant (CEREVANCE)
Jun 30, 2011·Immunology·Marius StriogaDainius Characiejus
Jul 31, 2012·Clinical & Developmental Immunology·Gianfranco LaulettaLoredana Sansonno
Jan 29, 2013·American Journal of Clinical Pathology·Kristy L WolniakLo Ann C Peterson
May 22, 2013·Archivum Immunologiae Et Therapiae Experimentalis·José Carlos Jaime-PérezDavid Gómez-Almaguer
Jun 13, 2013·Blood·Paul L SwiecickiMorie A Gertz
Jan 15, 2014·Blood Cells, Molecules & Diseases·George B Segel, Marshall A Lichtman
Jan 15, 2014·Autoimmunity Reviews·Garrett F BassJoseph M Tuscano
Mar 29, 2014·Asian Journal of Transfusion Science·R K Chaudhary, Sudipta Sekhar Das
Oct 2, 2014·Haematologica·Alberto Zanella, Wilma Barcellini
Dec 24, 2015·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Wilma Barcellini
Feb 2, 2016·Autoimmunity·S Ju SmirnovaA B Sudarikov
Jun 1, 2016·Frontiers in Immunology·Emily R Mercadante, Ulrike M Lorenz
Sep 1, 2016·Immunology and Cell Biology·Eoin F McKinney, Kenneth Gc Smith
Dec 23, 2016·British Journal of Haematology·Quentin A HillUNKNOWN British Society for Haematology
Feb 13, 2017·The Medical Clinics of North America·Howard A Liebman, Ilene C Weitz
Apr 1, 2017·Blood·Ronald S GoNeil E Kay

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst (lyse), leading to an insufficient number of oxygen-carrying red blood cells in the circulation. Discover the latest research on AIHA here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.