Features of recrudescent chloroquine-resistant Plasmodium falciparum infections confer a survival advantage on parasites and have implications for disease control

Transactions of the Royal Society of Tropical Medicine and Hygiene
S M HandunnettiK N Mendis

Abstract

This paper reports on the features of recrudescent infections of chloroquine-resistant Plasmodium falciparum (CQRPf) malaria from a study in vivo of patients from a malaria endemic (n = 527) and non-endemic (n = 129) region of Sri Lanka where the incidence of RI resistance was 30% and 55%, respectively. In both groups of patients, the recrudescent infections which emerged after treatment of the primary infection with chloroquine (CQ) and primaquine had significantly lower peripheral parasitaemia (0.036% and 0.108% in endemic and non-endemic patients, respectively) compared to their primary infections (mean parasitaemia 0.13% and 0.49%; P = 0.021 and 0.002, respectively). The recrudescences of CQ resistant infections also gave rise to clinical disease of markedly reduced severity (average clinical scores of 10.1 and 8.2) compared to their primary infections (average clinical scores of 12.4 and 12.3; P = 0.003 and 0.001, respectively, in endemic and non-endemic patients). CQ resistant recrudescent infections therefore had a lower probability of being diagnosed and treated. In endemic patients, a higher proportion of CQRPf infections (57%) had gametocytaemia compared to the chloroquine sensitive ones (29%) (P = 0.014, chi 2 = 5.96...Continue Reading

References

Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·R N WilkinsonD J Gould
Oct 1, 1991·The American Journal of Tropical Medicine and Hygiene·A C Gamage-MendisK N Mendis
Apr 1, 1990·The American Journal of Tropical Medicine and Hygiene·C MendisK N Mendis
Mar 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Björkman, P A Phillips-Howard
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·S ThaithongG H Beale
Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·J Fonseka, K N Mendis
Jul 7, 1984·Lancet·M IsaäcsonW L Sieling
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·W H WernsdorferH Kollaritsch
Jan 1, 1994·The Journal of Experimental Medicine·M K PereraK N Mendis
Nov 1, 1991·Parasitology Today·W H Wernsdorfer

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Citations

Nov 1, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Eltayeb AliHamza A Babiker
Nov 18, 1997·International Journal for Parasitology·G A Butcher
Jul 31, 1999·International Journal for Parasitology·A G Buckling, A F Read
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·C J DrakeleyG A Targett
Aug 17, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Charles O ObonyoAggrey J Oloo
Jul 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·H M KodisingheK N Mendis
Oct 9, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J Mackinnon, I M Hastings
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PostigoH A Pérez
Oct 17, 2006·Parasitology Today·J C Koella
Apr 22, 1997·Proceedings. Biological Sciences·A G BucklingA F Read
Sep 25, 2004·Antimicrobial Agents and Chemotherapy·Rachel L HallettAli Alloueche
Jan 9, 2001·Clinical Microbiology Reviews·R S Phillips
Aug 14, 2003·Malaria Journal·Olivier J T BriëtFelix P Amerasinghe
Jul 26, 2008·Malaria Journal·Lareef ZubairStephen J Connor
Jun 17, 1999·Lancet·N J WhiteP Olliaro
Aug 28, 1999·Experimental Parasitology·A BucklingA Read
Sep 3, 2003·Tropical Medicine & International Health : TM & IH·A Sowunmi, B A Fateye
Feb 27, 2014·Malaria Journal·Andrea M McCollumDavid J Bacon
Jul 19, 2006·Trends in Parasitology·Chris DrakeleyGeoffrey A T Targett
Aug 11, 2016·PLoS Neglected Tropical Diseases·Rou ZhangBruce Russell
Sep 18, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Antoine BerryJean-François Magnaval
Jan 17, 2009·Memórias do Instituto Oswaldo Cruz·Akintunde SowunmiChristian T Happi
Jul 17, 2018·Parasitology·Divya BeriUtpal Tatu

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