Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Michael P MalterRainer Surges

Abstract

To investigate determining factors of the ictal scalp EEG pattern at seizure onset and its predictive value for postsurgical outcome in people with unilateral MTLE due to hippocampal sclerosis (MTLE-HS). Review of consecutive people with chronic MTLE-HS undergoing presurgical video-EEG telemetry. Exclusion criteria were additional epileptogenic lesions or seizure generators or compromised EEG traces at seizure-onset. Mixed linear or logistic regression models were used. Inclusion of 63 patients with 219 seizures with a favorable outcome (no seizures or auras only) in 43 patients at last follow-up. Rhythmic activity at seizure-onset (RA) had a frequency of 4.7±1.5/s (range 1-8/s), mostly localized in the anterior temporal region. Postsurgical seizure outcome was not associated with any clinical or electrophysiological feature. RA in the delta-band was more often observed with shorter epilepsy duration (p=0.002). RA on scalp EEG gets faster with increasing epilepsy duration, possibly via time-dependent alterations of epileptogenic networks. Neither the frequency of RA nor other EEG-features appeared to predict postsurgical seizure outcome. The results challenge the view that if patients with apparent MTLE display RA in the delta-...Continue Reading

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Citations

Aug 26, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kazutaka Jin, Nobukazu Nakasato

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