Features of urine S100B and its ability to rule out intracranial hemorrhage in patients with head trauma: a prospective trial.

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
Tomas VedinPer-Anders Larsson

Abstract

Traumatic brain injury causes morbidity and mortality worldwide. S100B is the most documented emergency brain biomarker and its urine-assay might be advantageous because of easier sampling. The primary aim was to evaluate urine S100B's ability to rule out intracranial hemorrhage. Secondary aims included S100B temporal pattern for 48 h post-trauma and chemical properties of urine that affect urine S100B. Patients with head trauma were sampled for serum and urine S100B. Patients who were admitted for intracranial hemorrhage were sampled for 48 h to assess S100B-level, renal function, urine-pH, etc. RESULTS: The negative predictive value of serum S100B was 97.0% [95% confidence interval (CI) 89.5-99.2%] and that of urine S100B was 89.1% (95% CI 85.5-91.9%). The specificity of serum S100B was 34.4% (95% CI 27.7-41.6%) and that of urine was 67.1% (95% CI 59.4-74.1%). Urine-pH correlated strongly with urine S100B during the first 6-h post-trauma. Trend-analysis of receiver operator characteristics of S100B in serum, urine the arithmetic difference between serum and urine S100B showed the largest area under the curve for arithmetic difference, which had a negative predictive value of 93.1% (95% CI 89.1-95.8%) and a specificity of 71.8...Continue Reading

References

Feb 19, 2002·Kidney International·Kamel S KamelMitchell L Halperin
Apr 16, 2004·Journal of Rehabilitation Medicine·J David CassidyUNKNOWN WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury
Sep 9, 2005·British Journal of Neurosurgery·J UndénB Romner
Nov 29, 2005·Acta neurochirurgica·F TagliaferriJ Kraus
Mar 1, 2006·Journal of Neurotrauma·Will TownendFiona Lecky
Aug 10, 2006·BMJ : British Medical Journal·Jean-Luc af GeijerstamUNKNOWN OCTOPUS Study Investigators
Feb 22, 2007·Veterinary Clinical Pathology·William J ReaganSuzanne Botts
May 25, 2007·Neurocritical Care·Johan UndénBertil Romner
Jul 16, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Magnus HallénMikael Bergenheim
Aug 25, 2010·The Journal of Trauma·Magnus HallénMikael Bergenheim
Oct 16, 2010·Emergency Medicine Journal : EMJ·Søren Ohrt-NissenLars S Rasmussen
Sep 29, 2011·Annals of Emergency Medicine·Drissa ZongoEmmanuel Lagarde
Oct 4, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ana Rodríguez-RodríguezJuan Miguel Guerrero
Dec 14, 2016·Acta neurochirurgica·Eric Peter ThelinBo-Michael Bellander
Feb 9, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Lawrence M LewisRobert D Welch
Mar 17, 2017·MMWR. Surveillance Summaries : Morbidity and Mortality Weekly Report. Surveillance Summaries·Christopher A TaylorLikang Xu

❮ Previous
Next ❯

Citations

Mar 12, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dana SlavoacaPieter Vos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.