Features of varicella zoster virus myelitis and dependence on immune status

Journal of the Neurological Sciences
Chih-Hsien HungLong-Sun Ro

Abstract

Myelitis is a rare complication of varicella zoster virus (VZV) infection and is more prevalent in immunocompromised individuals. Clinical features, outcomes, and presentations vary. The aim of the current study was to compare the clinical presentations of our patients with those reported in the literature, and to evaluate the differences in clinical features between immunocompromised and immunocompetent patients. A review of the literature on VZV myelitis was carried out by searching PUBMED from 1980 to 2012. Clinical features of our cases and those in the literature were compared. There were 5 cases at our hospital and 26 were reported in the literature. Seventeen patients were immunocompromised (54.8%), and most had acquired immune deficiency syndrome (AIDS). Typical presentations (skin lesions followed by myelopathy at the corresponding level) were observed in 14 patients (45.2%). The immunocompromised patients were prone to atypical presentations (p<0.05). Outcomes were good in immunocompetent patients and relatively poor in immunocompromised patients (p<0.05). Anti-herpetic agents had no statistically significant effect on outcomes in immunocompromised patients (p=0.280), but could reduce mortality rate in AIDS patients (...Continue Reading

References

May 1, 1990·The American Journal of Medicine·H M HellerR T Steigbigel
Feb 1, 1972·Annals of Internal Medicine·S SchimpffJ Block
Sep 1, 1983·The Journal of Antimicrobial Chemotherapy·H H BalfourB Bean
Sep 12, 1981·British Medical Journal·R N CorstonR B Godwin-Austen
Oct 14, 1982·The New England Journal of Medicine·R J WhitleyC A Alford
Sep 1, 1995·Anesthesia and Analgesia·Y OdaM Fujimori
Jan 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P R MeylanR Sahli
Oct 1, 1994·Neurology·D H GildenR Mahalingam
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T GuffondP Wattre
May 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E Gómez-TortosaF Soriano
Oct 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F A ManianK H Fulling
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F LionnetF Rozenberg
Oct 1, 1996·Neurology·S M de SilvaS Houff
Mar 4, 2000·The New England Journal of Medicine·D H GildenR J Cohrs
Feb 12, 2004·The Pediatric Infectious Disease Journal·Elena ChiappiniRavi Jhaveri
Aug 21, 2004·European Neurology·H Jacobus GilhuisPeter Portegies
Jun 3, 2005·The New England Journal of Medicine·Ann Arvin
Mar 9, 2007·Journal of Neurology·R ToledanoJ Masjuán
Oct 20, 2007·Lancet Neurology·Israel SteinerAndrew R Pachner
Feb 12, 2008·The Journal of Infectious Diseases·Satish K MehtaDuane L Pierson
Feb 18, 2009·Neurology·C Young-BarbeeD H Gilden
Feb 23, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Tadashi UmeharaSoichiro Mochio
Mar 10, 2016·Journal of Pediatric Surgery·Patrick B MurphySarah A Jones

❮ Previous
Next ❯

Citations

Mar 5, 2013·Journal of Neurosurgery. Spine·Mark Daniel Anderson, Sudhakar Tummala
May 28, 2014·Case Reports in Neurological Medicine·Karen LynchMithila Vullaganti
Jun 27, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sarah BerthTibor Valyi-Nagy
Nov 26, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Marisa S PrelackJoseph R Berger
May 22, 2016·Infectious Diseases·John F McNamaraRobert D Henderson
Oct 27, 2015·American Journal of Physical Medicine & Rehabilitation·Anna Markh, Stanley Wainapel
Apr 26, 2020·Current Opinion in Infectious Diseases·Maria A NagelAndrew N Bubak
Oct 12, 2013·Postgraduate Medicine·Mazen S Bader
Aug 9, 2019·Medicine·Zenshi MiyakeAkira Tamaoka
Jan 17, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G N LevitskyS V Serkov
Dec 18, 2020·Frontiers in Neurology·Hiroto EguchiYasushi Shimo
Sep 1, 2021·BMJ Case Reports·Anjely Pulparampil SebastianDominic Benjamin

❮ Previous
Next ❯

Related Concepts

Related Feeds

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
E Liana FalconeH Clifford Lane
Journal of the Chinese Medical Association : JCMA
Cheng-Chia LeeHenrich Cheng
Neurología : publicación oficial de la Sociedad Española de Neurología
J Montero TinnirelloE Santos Armentia
© 2021 Meta ULC. All rights reserved