Febrile transfusion reaction caused by AB0-incompatible platelet transfusion

Infusionstherapie : offizielles Organ der Deutschen Arbeitsgemeinschaft für Künstliche Ernährung (DAKE) ; offizielles Organ der Österreichischen Arbeitsgemeinschaft für Klinische Ernähru (AKE) ; offizielles Organ der Deutschen Gesellschaft für Transfusion
P M WinterP Höcker

Abstract

A febrile transfusion reaction caused by strong isoagglutinins in the patients serum is reported. The reaction resulted from a transfusion of group A platelets in a group 0 patient; the recipients' serum contained high titered isohemagglutinin (Anti-A 1:8192) capable of lysing bloodgroup A1 red cells up to a titer of 1:8. Moreover, the serum showed a strong positive thrombocytotoxic reaction with the platelets of the donor and some other group A individuals, but remained negative with group 0, and turned to negative reaction with group A samples after neutralization with bloodgroup substance. We conclude that pretransfusion testing of group 0 donors and recipients for isohemolysins combined with platelet crossmatching may prevent febrile reactions.

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