Febuxostat.

Drugs
Philip I HairGillian M Keating

Abstract

*Febuxostat is an orally administered, non-purine, selective inhibitor of xanthine oxidase approved for the management of chronic hyperuricaemia in patients with gout. *In a randomized, double-blind, dose-ranging study in patients with gout and hyperuricaemia, significantly more recipients of febuxostat 40-120 mg/day than placebo had serum urate levels of < 6.0 mg/dL after 4 weeks of treatment. *Serum urate levels were reduced below 6.0 mg/dL at the last three monthly observations in a significantly greater proportion of patients with gout and hyperuricaemia receiving febuxostat 80 or 120 mg once daily than in those receiving allopurinol 300 mg once daily in a 52-week, randomized, double-blind trial (FACT). *Similarly, febuxostat 80, 120 or 240 mg once daily showed significantly greater urate-lowering efficacy than allopurinol 100 or 300 mg once daily in a 28-week, randomized, double-blind, placebo-controlled trial (APEX) in patients with gout and hyperuricaemia. *Long-term treatment with febuxostat for up to 4 years or more reduced the incidence of gout flares to (or close to) zero. *Febuxostat was generally well tolerated in clinical trials, including extension studies lasting > or = 4 years, with most treatment-related adver...Continue Reading

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Citations

Dec 4, 2012·Journal of Chromatographic Science·Mathrusri Annapurna MukthinuthalapatiChitaranjan Mohapatro
Feb 20, 2010·Clinical Interventions in Aging·Mattheus K Reinders, Tim L Th A Jansen
Aug 5, 2011·Drugs & Aging·Lisa K Stamp, Sarah Jordan
Jan 25, 2011·Bioorganic & Medicinal Chemistry·Kevin K-C LiuJin Li
Aug 14, 2012·Pharmaceutical Biology·Yanfen NiuLing Li
Apr 10, 2012·Bioorganic & Medicinal Chemistry·Chandrika B-RaoH Sivaramakrishnan
Sep 5, 2019·Food & Function·Lin ChenZhao-Cheng Ma
Oct 2, 2009·Deutsches Ärzteblatt International·Anne-Kathrin TauscheUlf Müller-Ladner
Dec 21, 2010·Chemico-biological Interactions·Yanfen NiuLing Li

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