Fecal and Blood Microbial 16s rRNA Gene Alterations in Chinese Patients with Multiple System Atrophy and Its Subtypes

Journal of Parkinson's Disease
Juanjuan DuSheng-Di Chen

Abstract

To explore the alterations of microbial 16s ribosomal (rRNA) gene in the feces and blood of Chinese patients with multiple system atrophy (MSA) and its relationships with clinical features. 40 MSA patients (MSA-P/MSA-C: 23/17) and their healthy spouses were recruited. Fecal and blood microbiota were investigated by high-throughput IllUmina Miseq sequencing targeted on the V3-V4 functional region of 16s rRNA gene. The relationships between microbiota and clinical characteristics were analyzed. The abundances of Lactobacillus, Gordonibacter, Phascolarctobacterium, and Haemophilus in feces and abundances of Leucobacter, and Bacteroides in blood were different between MSA patients and healthy controls (HC). Combining the taxa from feces and blood, six genera were identified to be predictive of MSA, achieving an area under the curve (AUC) of 0.853. The abundances of Phascolarctobacterium and Ruminococcus in feces were lower in MSA-P than those in MSA-C. The abundances of Blastococcus, Bacillus, and Acinetobacter in blood were different between MSA subtypes. These five genera differentiated MSA subtypes with an AUC of 0.898. Functional predictions indicated that gene functions involving biosynthetic metabolism and bacterial secretion...Continue Reading

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Citations

Aug 28, 2020·Brain : a Journal of Neurology·Yiwei QianQin Xiao
Nov 29, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kathryn A Chung, Ronald F Pfeiffer
Aug 31, 2021·Cancer Letters·Haiming ChenMantang Qiu

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Methods Mentioned

BETA
blood collection
PCR

Software Mentioned

Mothur
R
PICRUSt
ANOSIM
STAMP
Cladogram
LEfSe

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