Fecal Calprotectin as an Activity Marker of Inflammatory Bowel Disease in Children

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Elzbieta Krzesiek

Abstract

Children constitute 20% of patients with inflammatory bowel diseases (IBD). Still there is a search for a perfect marker for this group of patients which would help in the diagnosis of the disease, in determinating its activity and in monitoring the treatment. Evaluate the usefulness of the application of calprotectin measurement in stool samples from children with IBD, as a marker of the severity of inflammation. We analysed 156 patients: 58 with ulcerative colitis (UC), 67 with Crohn's disease (CD), and 31 from the control group. In all patients the concentration of calprotectin in the sample of feces, markers of inflammation and hemoglobin were measured. Concentration of calprotectin in feces of patients with IBD was above the normal range in all patients with moderate and severe disease and in the majority with mild disease or in remission, but it was normal in all patients from the control group. Elevated concentration of fecal calprotectin (FC) was observed in the majority of patients with IBD, but in none from the control group. The number of patients with elevated FC concentration increased together with the disease activity. FC concentration was higher in patients with severe and moderate disease activity. FC concentra...Continue Reading

Citations

Aug 31, 2016·European Journal of Pediatrics·Daniël R HoekmanMarc A Benninga
Jun 3, 2018·World Journal of Pediatrics : WJP·Anna MedkovaVladimir Mihal
Apr 3, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Olga Maria NardoneFabiana Castiglione

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