Fecal calprotectin in clinical practice: a noninvasive screening tool for patients with chronic diarrhea

Journal of Clinical Gastroenterology
Anna LicataAntonio Craxì

Abstract

Surrogate markers of colorectal inflammation are increasingly being recognized as important in differentiating organic from functional intestinal disorders. Fecal calprotectin (FC) can be easily measured in the stool, being released by leukocytes in inflammatory conditions. We evaluated FC as an index of inflammation in consecutive outpatients referred for colonoscopy for chronic, nonbloody diarrhea. Stool specimens of 346 outpatients with chronic, nonbloody diarrhea, referred for colonoscopy, were measured for FC levels. The proportion of patients correctly diagnosed with the test and the relationship with endoscopic and histologic findings were measured. Abnormal endoscopic findings were detected in 104 patients (30.1%). Histologic findings included 142 patients (41.0%) with inflammation and 204 (59.0%) without inflammation. Fecal excretion of calprotectin significantly correlated with the finding of inflammation at endoscopy and histology (P<0.0001). When 150 mcg/g of stool was used as the upper reference limit, FC showed 75.4% sensitivity and 88.3% specificity, with 81.7% positive and 83.7% negative predictive values for histologic inflammation. In outpatients referred for colonoscopy a measurement of FC is accurate to iden...Continue Reading

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Citations

Nov 28, 2013·World Journal of Gastroenterology : WJG·Gerhard RoglerPeter L Lakatos
Apr 21, 2017·Scandinavian Journal of Gastroenterology·Lukasz KwapiszMahmoud Mosli
May 29, 2015·Arquivos De Gastroenterologia·Lorete Maria da Silva KotzePaulo Gustavo Kotze
Apr 25, 2014·The Medical Clinics of North America·Mark E Pasanen
Jul 22, 2017·The Cochrane Database of Systematic Reviews·Gregor NovakReena Khanna
Feb 25, 2014·Inflammatory Bowel Diseases·Uri KopylovErnest Seidman
Nov 6, 2014·Scandinavian Journal of Gastroenterology·Gian Paolo CavigliaFrancesca Bresso
Jun 13, 2012·Journal of Clinical Gastroenterology·John R Cangemi
Sep 23, 2016·Clinical Medicine Insights. Gastroenterology·Maria Cappello, Gaetano Cristian Morreale
Apr 20, 2019·Korean journal of pediatrics·Su Jin Jeong
Mar 10, 2017·Expert Review of Gastroenterology & Hepatology·Paula Ministro, Diana Martins
Aug 15, 2021·Revista De Gastroenterología De México·O Gómez-Escudero, J M Remes-Troche
Jun 3, 2021·Revista de gastroenterología de México·O Gómez-Escudero, J M Remes-Troche

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