Fecal calprotectin in the prediction of postoperative recurrence of Crohn's disease in children and adolescents

Journal of Pediatric Surgery
Maria HukkinenKaija-Leena Kolho

Abstract

Fecal calprotectin (FC) correlates with endoscopic recurrence of Crohn's disease (CD) in adults but has not been studied among children postoperatively. We aimed to analyze whether FC relates with postoperative CD recurrence in children. Altogether 51 postoperative endoscopies and FC measurements from 22 patients having undergone surgery for CD at age ≤18years were included. Ileocecal resection (n=15), small bowel resection (n=6), or left hemicolectomy (n=1) was performed at median age of 15.1 (interquartile range 14.4-17.6) years. Following surgery, FC decreased significantly (659 vs. 103μg/g, p=0.001). During median follow-up of 5.7 (4.2-7.7) years, either endoscopic or histological recurrence occurred in 17 patients (77%). FC >139μg/g at time of endoscopy or FC increase of 79μg/g compared to first postoperative value was suggestive of endoscopic recurrence (Rutgeerts score i2-i4), while FC >101μg/g or increase of 21μg/g indicated histological recurrence. Best accuracy for prediction of recurrence was obtained by combining FC at endoscopy and the postoperative increase of FC. The corresponding AUROC values were 0.74 (95% 0.58-0.89) for endoscopic recurrence whereas 0.81 (95% CI 0.67-0.95) for histological recurrence. FC is a ...Continue Reading

References

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Citations

Jun 21, 2016·Expert Review of Clinical Immunology·Kaija-Leena Kolho, Antti Ainamo
Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Jorge Amil-DiasUNKNOWN IBD Working Group of ESPGHAN (IBD Porto Group)
Jul 15, 2017·Expert Review of Gastroenterology & Hepatology·Takayuki Yamamoto, Takahiro Shimoyama
Mar 2, 2017·Journal of Pediatric Gastroenterology and Nutrition·Kristyna ZarubovaJiri Bronsky
Aug 24, 2018·Journal of Crohn's & Colitis·Christian MaaserUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Oct 20, 2019·Paediatric Drugs·Anat Yerushalmy-Feler, Amit Assa
Mar 20, 2019·World Journal of Gastroenterology : WJG·Alice Jane FosterKevan Jacobson
Feb 21, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Emilio J Laserna-Mendieta, Alfredo J Lucendo
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele
Jun 20, 2021·Gut·Almina JukicTimon E Adolph
Aug 28, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Kristyna ZarubovaJiri Bronsky

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